环孢素A在小儿肾病综合征中的应用

环孢素A(cyclosporine A,CsA)自1986年开始用于治疗儿童肾病综合征(NS),是目前激素依赖或耐药型NS的选择性治疗药物之一,特别是在细胞毒性药物不耐受或出现不良反应的患儿,长期应用安全性和耐受性均较好。但在应用期间必须监测CsA的血药浓度和肾功能,对接受长期持续CsA治疗的儿童每2～3年进行1次肾活检,以发现肾毒性的组织学证据。

Application of cyclosporine A in children with nephrotic syndrome

Cyclosporin A (CsA) has been used in the treatment of idiopathic glomerular disease associated with the nephrotic syndrome (NS) in children since 1986.At present,CsA has been alternatively used in the treatment of patients with steroid-dependent or resistant NS,especially in the patients with cytotoxic agent intolerance or with occurrence of serious toxic side effects for steroids and cytotoxic drugs.A growing body of studies shows that it is safe and well tolerated for a long-term CsA therapy.Regular monit...