Chronic myeloid leukemia: current perspectives |
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Authors: | Zhang Yanming Rowley Janet D |
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Institution: | Department of Pathology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Tarry Building 7-729, Chicago, IL 60611, USA. yanming-zhang@northwestern.edu |
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Abstract: | Chronic myeloid leukemia (CML), characterized by the t(9;22) and BCR/ABL1 fusion, is a disease model for studying the mechanisms of genetic abnormalities in leukemogenesis. The detection of the t(9;22), characterization of the BCR/ABL fusion, and the discovery of imatinib have elegantly reflected the success of our research efforts in CML. However, genomic instabilities that lead to the formation of the BCR/ ABL1 fusion are not fully understood. It is important to understand how various genes that are involved in regulating the signaling pathway and epigenetic deregulation cooperate with the BCR/ABL1 fusion in the initiation and progression of CML. |
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