A study on lung toxicity of respirable hard metal dusts in rats |
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| Affiliation: | 1. National Institute of Occupational Health, Budapest, H-1450, P.O. Box 22, Hungary;2. Department of Pathology, Dokkyo Medical University, Mibu, Tochigi, Japan;1. Department of Civil, Environmental & Mechanical Engineering, University of Trento, via Mesiano, 77, 38123 Trento, Italy;2. Department of Civil, Environmental & Mechanical Engineering, Laboratory of Bio-Inspired and Graphene Nanomechanics, University of Trento, via Mesiano, 77, 38123 Trento, Italy;3. Center for Materials and Microsystems, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Povo (Trento), Italy;4. School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom;1. INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada;2. CO2 Solutions Inc., 2300, rue Jean-Perrin, Québec, Québec G2C 1T9 Canada;3. Department of Civil Engineering, University of Nebraska-Lincoln, N104 SEC PO Box 886105, Lincoln, NE 68588-6105, USA;1. Department of Mechanical, Chemical and Materials Engineering, University of Cagliari, via Marengo 2, I-09123 Cagliari, Italy;2. Department of Industrial Engineering, University of Salerno, via Giovanni Paolo II, 132, I-84084 Fisciano (Salerno), Italy;3. Institute for Polymers, Composite and Biomaterials (IPCB), National Research Council (CNR), P.le E. Fermi 1, I-80055 Portici (Napoli), Italy;1. Technology and Society Lab, EMPA, Lerchenfeldstrasse 5, 9014 St. Gallen, Switzerland;2. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland |
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| Abstract: | The aetiology of hard metal lung disease has not been clarified so far. The pulmonary toxicity of respirable dusts collected in a hard metal factory was studied in vivo in rats. The effect of the samples was examined 1, 4, 7 and 30 days after single intratracheal injection. Lactate dehydrogenase (LDH), acid phosphatase (AP), protein and phospholipid were determined in cellfree bronchoalveolar lavage (BAL) and lung tissue. The lungs and regional lymph nodes were processed histologically. Lung toxicity of the samples collected during hard metal production varied. Samples containing considerable amount of cobalt dissolved upon acid treatment were found to induce inflammation. It has been established that the biological effect of samples of identical composition is changed by heat treatment and pre-sintering. Our examinations seem to prove that cobalt plays a prominent role in the development of pathological alterations. |
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