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| 细胞周期蛋白D1基因多态与人结直肠癌遗传易感性 | |
| 引用本文： | 朱忠政,王爱忠,贾杭若,金夏祥,何向蕾,朱冠山.细胞周期蛋白D1基因多态与人结直肠癌遗传易感性[J].解剖科学进展,2008,14(4). |
| 作者姓名： | 朱忠政 王爱忠 贾杭若 金夏祥 何向蕾 朱冠山 |
| 作者单位： | 1. 解放军第--三医院病理科,浙江,宁波,315040 2. 宁波市李惠利医院病理科,浙江,宁波,315041 3. 阿斯利康中国创新中心,上海,201203 |
| 基金项目： | 国家自然科学基金资助项目，南京军区医学科学技术研究"十一五"计划资助项目 |
| 摘 要： | 目的探讨细胞周期蛋白D1(Cyclin D1)基因第870位点单核苷酸多态(G870A)与结直肠癌(colorectal cancer,CRC)遗传易感性的关系。方法采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)方法,检测345例CRC与670名对照的G870A基因型分布及差异。结果CRC和对照两组人群的Cyclin D1 G870A基因型分布差异无统计学意义(P>0.05)。与GG基因型相比,GA、AA基因型及A等位基因携带者(GA及AA基因型)的CRC风险分别为1.08倍(95%CI=0.75～1.54)、1.01倍(95%CI=0.68～1.51)及1.06倍(95%CI=0.75～1.49)。经性别、年龄、肿瘤位置、组织学分化程度和Dukes分期等因素分层分析,结果均显示G870A与CRC发病风险无显著性相关。结论Cyclin D1 G870A多态与宁波地区人群的CRC发病风险无相关性。 |
| 关 键 词： | 结肠直肠肿瘤 基因 Cyclin D1 基因多态 遗传易感性 人 |
Polymorphism of Cyclin D1 and Genetic Susceptibility to Colorectal Cancer of Human |
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| ZHU Zhong-zheng,WANG Ai-zhong,JIA Hang-ruo,et al.Polymorphism of Cyclin D1 and Genetic Susceptibility to Colorectal Cancer of Human[J].Progress of Anatomical Sciences,2008,14(4). | |
| Authors: | ZHU Zhong-zheng WANG Ai-zhong JIA Hang-ruo |
| Institution: | ZHU Zhong-zheng,WANG Ai-zhong,JIA Hang-ruo,et al (Department of Pathology,No. 113 Hospital of People\'s Liberation Army,Ningbo 315040 China) |
| Abstract: | Objective To investigate the possible association between the G870A polymorphism of Cyclin D1 gene and susceptibility to colorectal cancer (CRC) in chinese population. Methods The Cyclin D1 G870A genotype was determined by PCR-based restriction fragment length polymorphism (RFLP) method in 345 CRC cases and 670 controls from Ningbo, Zhejiang province. Odds ratios (OR) for CRC and 95% confidence intervals (CI) from unconditional logistic regression models were used to evaluate relative risks. Potential risk ... |
| Keywords: | CyclinD1 |
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