香砂八珍汤联合肠内营养对消化道肿瘤术后患者免疫功能的影响

目的:观察香砂八珍汤联合肠内营养对消化道肿瘤术后患者营养状况、生活质量和免疫功能的影响。方法:将130例消化道肿瘤患者采用数字表法按随机分成对照组和观察组。对照组采用肠内营养,观察组在对照组治疗的基础上加用香砂八珍汤。两组疗程均为14 d。检测血清免疫球蛋白IgG,IgA,IgM,血T淋巴细胞亚群(CD3~+,CD4~+,CD4~+/CD8~+)和自然杀伤细胞(NK)水平,进行治疗前后SF-36健康调查量表评分,检测治疗前后血清白蛋白(Alb),前白蛋白(PA),血红蛋白(Hb)和转铁蛋白(TRF)水平。结果:治疗后观察组CD3~+,CD4~+,CD4~+/CD8~+和NK水平均较治疗前升高(P0.01),并高于对照组(P0.01);治疗后观察组IgG,IgA,IgM均比治疗前有所升高(P0.01),并高于对照组(P0.05,P0.01);治疗后观察组Alb,Hb水平高于对照组(P0.05),两组PA和TRF组间比较差异无统计学意义;治疗后观察组躯干功能(PF),社会功能(SF),情感职能(RE),生命活力(VT),精神健康(MH)和总体健康(GH)评分高于对照组(P0.05)。结论:香砂八珍汤联合肠内营养用于对消化道肿瘤术后患者,能改善患者免疫功能和营养情况,提高患者的生活质量,促进患者的康复。

Influence of Xiangsha Bazhen Decoction Combined with Enteral Nutrition on Postoperative Immune Functions of Patients with Gastrointestinal Tumor Surgery

Objective: To observe the influence of Xiangsha Bazhen decoction combined with enteral nutrition on nutritional status, quality of life and immune functions in patients with gastrointestinal tumor surgery. Method: One hundred and thirty patients with gastrointestinal tumors were randomly divided into control group and observation group. Patients in control group received enteral nutrition. Based on the treatment of control group, patients in observation group received additional Xiangsha Bazhen decoction. Course of treatment was 14 days for both groups. Levels of serum immune globulin IgG, IgA and IgM, T-lymphocyte subpopulations in blood(CD3⁺, CD4⁺ and CD4⁺/CD8⁺) and natural killer cell(NK) were measured. Before and after treatment, scores of SF-36 health survey scales were graded, and levels of serum albumin(Alb), prealbumin(PA), hemoglobin(Hb) and transferrin(TRF) were also detected. Result: Compared with the data before treatment, levels of CD3⁺, CD4⁺, CD4⁺/CD8⁺ and NK in observation group were increased after treatment(P<0.01), higher than those in control group(P<0.01). After treatment, levels of IgG, IgA and IgM in observation group were increased(P<0.01), and higher than those in control group(P<0.05, P<0.01). Levels of Alb and Hb after treatment were higher than those in control group, but there was no statistically significant difference in PA and TRF between two groups. Scores of pars trunci function(PF), social function(SF), role emotional(RE), vitality(VT), mental health(MH) and general health(GH) after treatment were higher than those in control group(P<0.01). Conclusion: Xiangsha Bazhen decoction combined with enteral nutrition can ameliorate nutritional status and immune function, improve quality of life and promote the recovery of disease in the treatment of patients after gastrointestinal tumors.