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改性活性炭对甘露三糖吸附性能的影响
引用本文:韦迎春,闫明,李雪峰,刘莉莉,杨绪芳,乔善义,萧伟.改性活性炭对甘露三糖吸附性能的影响[J].世界科学技术-中医药现代化,2015,17(11):2415-2421.
作者姓名:韦迎春  闫明  李雪峰  刘莉莉  杨绪芳  乔善义  萧伟
作者单位:江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001,江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001,江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001,江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001,江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001,军事医学科学院药物毒物研究所 北京 100850,江苏康缘药业股份有限公司 连云港 222001;中药制药过程新技术国家重点实验室 连云港 222001
基金项目:科学技术部国家重大新药创制项目(2013ZX09402203):现代中药创新集群与数字制药技术平台,负责人:王振中。
摘    要:目的:本研究旨在探讨硝酸、氨水对活性炭吸附性能的影响,评价改性活性炭对甘露三糖的吸附性能。方法:采用不同浓度的硝酸、氨水对活性炭进行改性处理,考察改性后活性炭对苯、碘、亚甲基蓝的吸附性能变化,并考察其对甘露三糖的吸附性能。结果:经硝酸、氨水改性后活性炭对亚甲基蓝、碘、苯的吸附性能有一定变化;而经硝酸改性后的活性炭对甘露三糖的吸附性能降低,经氨水改性后的活性炭对甘露三糖的吸附性能增强。结论:硝酸、氨水处理能使活性炭的孔隙结构发生变化。经硝酸改性后的活性炭对甘露三糖的吸附性能降低,而氨水改性后的活性炭对甘露三糖的吸附能力升高,说明经氨水改性后的活性炭适合甘露三糖的吸附,且对碘的吸附能力的强弱反映了活性炭对甘露三糖的吸附能力。

关 键 词:硝酸  氨水  改性  活性炭  甘露三糖  柱层析  吸附性能
收稿时间:2014/11/6 0:00:00
修稿时间:2015/4/10 0:00:00

Research on Adsorption Properties Changes of Mannotriose by Modified Activated Carbon
Wei Yingchun,Yan Ming,Li Xuefeng,Liu Lili,Yang Xufang,Qiao Shanyi and Xiao Wei.Research on Adsorption Properties Changes of Mannotriose by Modified Activated Carbon[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2015,17(11):2415-2421.
Authors:Wei Yingchun  Yan Ming  Li Xuefeng  Liu Lili  Yang Xufang  Qiao Shanyi and Xiao Wei
Institution:Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China,Institute of Pharmacology and Toxicology, Academy of Militar y Medical Sciences, Beijing 100850, China and Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China
Abstract:This study was aimed to explore the impact of activated carbon adsorption modified by different concentrations of nitric acid and ammonia, in order to examine the impact on adsorption of mannotriose by modified activated carbon. The activated carbon was processed by different concentrations of nitric acid and ammonia. And then, the adsorption capacity of benzene, iodine, methylene blue and the purification effects on mannotriose were measured. The results showed that the active carbon modified by nitric acid and ammonia had some changes of adsorptions for methylene blue, iodine and benzene. The purification effect of mannotriose with nitric acid-modified activated carbon was declined. The purification effect of mannotriose with ammoniamodified activated carbon was increased. It was concluded that the pore structure of activated carbon had been changed by nitric acid and ammonia. The adsorption capacity of nitric acid modified active carbon to mannotriose was declined. However, the adsorption capacity of ammonia modified active carbon to mannotriose was increased. It showed that ammonia modified active carbon was suitable for the purification of mannotriose. And the adsorption capacity of iodine reflected the adsorption capacity of mannotriose by active carbon.
Keywords:Nitric acid  ammonia  modified  activated carbon  manninotriose  column chromatography  adsorption
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