新一代组织工程细胞支架的研究进展

细胞支架是构建组织工程器官或组织的重要基础。在短短几十年内，细胞支架的研究与开发已取得了重大进展．促进了细胞支架从第一、二代向第三代发展。本文概述了第三代细胞支架的主要特征；介绍了细胞支架制备技术的最新进展，特别介绍了用超临界反溶剂（SAS）工艺制备第三代细胞支架的特点、优势及技术关键；指出了开发第三代细胞支架的重要途径之一：利用SAS工艺将天然、合成高分子材料与生物活性材料这三类材料进行复合，制备性能可调、综合性能优良的细胞支架；并提出了按此途径尚需开展的主要研究内容和要达到的主要目标。

Research Progress of the New Generation of Scaffolds

Scaffold is critical in building a tissue-engineered organ or tissue.After a short period of fruitful development,the scaffold has been on its way from the first and second generations to the third generation.In this paper,the main characteristics of the third generation scaffold are discussed.The latest developments of the preparative technologies of scaffolds are introduced with the emphasis on the supercritical anti-solvent(SAS) process and its distinguishing features,outstanding advantages and key techniques.It is pointed out that an important way of developing the third generation scaffolds with excellent and adjustable structural,mechanical and biological characteristics is to prepare the scaffolds by SAS process with the composite materials of three categories: synthetic biodegradable polymers,natural biodegradable polymers and bioactive materials.By this way,what is studied and which is achieved are also proposed.