非高密度脂蛋白胆固醇与冠心病的相关性研究

目的探讨非高密度脂蛋白胆固醇(non-HDL-C)与冠心病的关系。方法对连续372例冠脉造影患者的血脂及冠脉造影结果回顾性分析。冠脉造影阴性114例为对照组,冠脉造影阳性258例为冠心病组,冠心病组根据冠脉病变支数分为单支病变组(104例)和双支及三支病变组(154例),对以上各组的血脂及non-HDL-C结果进行比较。结果①与冠脉造影阴性组比较,冠脉造影阳性组non-HDL-C水平明显增高。②在冠脉造影阳性组,non-HDL-C水平随病变支数增加而上升。结论 non-HDL-C与冠状动脉粥样硬化病变关系密切,控制non-HDL-C在冠心病的防治中有重要意义。

Relation between non-high density lipoprotein-cholesterol and coronary heart disease

Objective To investigate the relation between non-high density lipoprotein-cholesterol （non-HDL-C） and coronary heart disease. Methods Totally 372 cases who underwent coronary angiography （CAG） were divided into CHD group who was positive in CAG （ n = 258） and controlled group who was negative in CAG （ n = 114）, comparing for the blood lipid and non-HDL-C between two groups. CHD group were divided into single branch group and two or three branch group, comparing for the blood lipid and non-HDL-C between two groups. Results ①Comparing to the controlled group, the level of non-HDL-C in CHD group increased with statistical significance（P 〈 0. 05 ）. ②Comparing to the single branch group, the levels of non-HDL- C in two or three branch group increased with statistical significance （P 〈 0. 05 ）. Conclusion Serum non- HDL-C is related to the severity of coronary artery lesions. It is important to control the level of non-HDL-C in order to treat and prevent coronary heart disease.