| 矽肺患者血清IL-17检测的临床意义 |
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| 引用本文： | 吴静,徐建,张映铭,王彩英. 矽肺患者血清IL-17检测的临床意义[J]. 放射免疫学杂志, 2009, 22(6): 623-625 |
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| 作者姓名： | 吴静 徐建 张映铭 王彩英 |
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| 作者单位： | 南京市胸科医院,210029;南京医科大学第一附属医院医学检验科,210029 |
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| 摘 要： | 目的：检测矽肺患者血清中IL-17水平,探讨其在矽肺发生发展中的意义。方法：采用酶联免疫吸附法,对45例Ⅰ期、22例Ⅱ期、9例Ⅲ期矽肺患者和52例非矽肺接尘工人的血清IL-17水平进行检测。结果：Ⅰ期矽肺组患者血清IL-17水平显著高于Ⅱ、Ⅲ期矽肺组及非矽肺接尘组,差异具有统计学意义（P〈0.01）。Ⅱ、Ⅲ期矽肺组与非矽肺接尘组相比,差异无统计学意义（P〉0.05）。结论：IL-17在矽肺形成早期呈高表达,且可能参与了矽肺发生发展的过程。
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| 关 键 词： | 白细胞介素-17 矽肺 |
Clinical Significance of Determination of Serum Interleukin-17 Levels in Patients with Silicosis |
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| Affiliation: | Wu Jing,Xu Jian,Zhang Yingming,et al.Nanjing Chest Hospital,Nanjing(210029),China2Department of Laboratory Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing(210029),China |
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| Abstract: | Objective To investigate the clinical significance of changes of serum interleukin（IL-17） levels in patients withsilicosis.Methods Serum levels of IL-17 were determined with ELISA in 76 patients with silicosis（stage Ⅰ n=45,stage Ⅱ,n=22,stage Ⅲ,n=9） and 52 controls.Results The serum IL-17 levels in patients with stage Ⅰ silicosis were significantly higher than those in controls（P〈0.01）.Howevers the serum IL-17 levels in patients with stage Ⅱ and stage Ⅲ silicosis were not significantly different from those in controls（P〈0.05）.Conclusion IL-17 is highly expressed in the early stage of silicosis and may play a role in the development of silicosis. |
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| Keywords: | interleukin-17 silicosis |
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