| Clinical Significance of VEGF-C and VEGFR-3 Expression in Non-small Cell Lung Cancer |
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| 引用本文： | 李军,洪梅,潘铁成. Clinical Significance of VEGF-C and VEGFR-3 Expression in Non-small Cell Lung Cancer[J]. 华中科技大学学报(医学英德文版), 2006, 26(5): 587-590. DOI: 10.1007/s11596-006-0528-1 |
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| 作者姓名： | 李军 洪梅 潘铁成 |
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| 作者单位： | Department of Cardiothoracic Surgery Tongji Hospital，Institute of Hematology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China，Department of Cardiothoracic Surgery，Tongji Hospital |
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| 摘 要： | The relationship between vascular endothelial growth factor-C (VEGF-C)/vascular en-dothelial growth factor receptor 3 (VEGFR-3) expression and clinicopathologic features of the patients with non-small cell lung cancer (NSCLC) was investigated. The expression of VEGF-C and VEGFR-3 was assessed in 65 patients with NSCLC by immunohistochemistry. The significance of VEGF-C and VEGFR-3 expression was analyzed statistically. The results showed that VEGF-C and VEGFR-3 were highly expressed in cytoplasm and membrane in lung cancer tissues with the positive rate being 55.4 % and 52.3 % respectively, while there was no expression in the normal lung tissues. The expression of VEGF-C was significantly increased in adenocacinoma as compared to other types of NSCLC (P<0.05). The VEGFR-3 expression was closely related with lymph node metastasis (P<0.01) and TNM stage (P<0.05). There was a positive correlation between the VEGF-C and VEGFR-3 expression in NSCLC patients (r=0.658, P<0.01). It is suggested that VEGFR-3 plays an important role in the lymphatic metastasis of NSCLC. The interaction between VEGF-C and VEGFR-3 may be deeply involved in the mechanism of lung cancer metastasis.
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| 关 键 词： | 肺癌 临床 基因表达 血管 |
| 收稿时间： | 2005-10-19 |
Clinical significance of VEGF-C and VEGFR-3 expression in non-small cell lung cancer |
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| Jun Li,Mei Hong,Tiecheng Pan. Clinical significance of VEGF-C and VEGFR-3 expression in non-small cell lung cancer[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(5): 587-590. DOI: 10.1007/s11596-006-0528-1 |
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| Authors: | Jun Li Mei Hong Tiecheng Pan |
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| Affiliation: | 1. Department of Cardiothoracic Surgery, Tongji Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China
2. Institute of Hematology, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | The relationship between vascular endothelial growth factor-C (VEGF-C)/vascular en-dothelial growth factor receptor 3 (VEGFR-3) expression and clinicopathologic features of the patients with non-small cell lung cancer (NSCLC) was investigated. The expression of VEGF-C and VEGFR-3 was assessed in 65 patients with NSCLC by immunohistochemistry. The significance of VEGF-C and VEGFR-3 expression was analyzed statistically. The results showed that VEGF-C and VEGFR-3 were highly expressed in cytoplasm and membrane in lung cancer tissues with the positive rate being 55.4 % and 52.3 % respectively, while there was no expression in the normal lung tissues. The expression of VEGF-C was significantly increased in adenocacinoma as compared to other types of NSCLC (P<0.05). The VEGFR-3 expression was closely related with lymph node metastasis (P<0.01) and TNM stage (P<0.05). There was a positive correlation between the VEGF-C and VEGFR-3 expression in NSCLC patients (r=0.658, P<0.01). It is suggested that VEGFR-3 plays an important role in the lymphatic metastasis of NSCLC. The interaction between VEGF-C and VEGFR-3 may be deeply involved in the mechanism of lung cancer metastasis. |
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| Keywords: | vascular endothelial growth factor-C vascular endothelial growth factor receptor 3 non-small cell lung cancer |
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