Crevicular Fluid and Serum Concentrations of Progranulin and High Sensitivity CRP in Chronic Periodontitis and Type 2 Diabetes |
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| Authors: | N Priyanka Minal Kumari Nitish Kalra P Arjun Savitha B Naik A R Pradeep |
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| Institution: | 1.Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka 560002, India;2.Bangalore Medical College and Research Institute, Bangalore, Karnataka 560002, India;3.Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, Karnataka 560002, India |
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| Abstract: | Introduction. This study was designed to correlate the serum and gingival crevicular fluid (GCF) levels of progranulin (PGRN) and high sensitivity C-reactive protein (hs CRP) in chronic periodontitis and type 2 diabetes mellitus (DM). Design. PGRN and hs CRP levels were estimated in 3 groups: healthy, chronic periodontitis, and type 2 DM with chronic periodontitis. Results. The mean PGRN and hs CRP concentrations in serum and GCF were the highest for group 3 followed by group 2 and the least in group 1. Conclusion. PGRN and hs CRP may be biomarkers of the inflammatory response in type 2 DM and chronic periodontitis. |
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