Fiber tracking of white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex in schizophrenia: A diffusion tensor imaging study |
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| Authors: | Shinsuke Kito Jiuk Jung Tetsuo Kobayashi Yoshihiko Koga |
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| Institution: | 1. Department of Neuropsychiatry, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan;2. Department of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan;1. Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA;2. Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA;1. University of Groningen, University Medical Center Groningen, Department of Neuroscience, NeuroImaging Center, Section Cognitive Neuropsychiatry, Groningen, The Netherlands;2. Department of Rehabilitation, Lentis Psychiatric Institute, Zuidlaren, The Netherlands;3. University of Groningen, Rob Giel Research Center, Groningen, The Netherlands;4. University of Groningen, University Medical Center Groningen, Program for Mood and Anxiety Disorders, Department of Psychiatry, Groningen, The Netherlands;5. University of Groningen, Department of Psychology, Groningen, The Netherlands;1. Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong Special Administrative Region, China;2. Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong Special Administrative Region, China;3. Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region, China;4. Department of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China;1. Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark;2. Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany;3. Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre;4. Department of Neurology, Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark;5. Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom;6. Neurobiological Research Unit, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark |
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| Abstract: | The goal of this study was to detect abnormalities in white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex using fiber-tracking technique. Diffusion tensor imaging was acquired in 20 patients with schizophrenia and 20 normal comparison subjects. Fiber tracking was performed on the anterior thalamic peduncle, and the tractography was used to determine the cross-sectional area, mean fractional anisotropy, and standard deviation of fractional anisotropy for every step separately in the right and left hemispheres. Compared with normal subjects, patients showed a significant reduction in the cross-sectional area of the left anterior thalamic peduncle. There were no significant differences for the mean fractional anisotropy bilaterally between the two groups, but significant differences for the standard deviation of fractional anisotropy in both hemispheres. Reduction in the cross-sectional area of the left anterior thalamic peduncle suggests the presence of the failure of left-hemisphere lateralization. In schizophrenic patients a significant increase of the standard deviation of fractional anisotropy raise the possibility that the inhomogeneity of white matter integrity, which is densely or sparsely distributed by site. These findings might provide further evidence for disruption of white matter integrity between the thalamus and the prefrontal cortex in schizophrenia. |
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