Effect of bismuth subgallate (a hemostatic agent) on bone repair; a histologic,radiographic and histomorphometric study in rats |
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| Authors: | S.A. Puia S.J. Renou E.A. Rey M.B. Guglielmotti C.E. Bozzini |
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| Affiliation: | 1. Department of Oral and Maxillofacial Surgery II, School of Dentistry, University of Buenos Aires, Argentina;2. Department of Oral Pathology, School of Dentistry, University of Buenos Aires, Argentina;3. Department of Physiology, School of Dentistry, University of Buenos Aires, Argentina;1. Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;2. Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran;3. Endodontology Research Group, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Cardiff, United Kingdom;1. Ministry of Health, Faculty of Dentistry, Tripoli University, Libya;2. Oral Biology, Faculty of Dentistry, Mansoura University, Egypt;3. Oral Pathology, Faculty of Dentistry, Mansoura University, Egypt;4. Oral Biology, Faculty of Oral and Dental Medicine, Delta University for Science and Technology, Gamasa, Mansoura, Egypt;1. School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;2. School of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;3. Department of Pharmaceutical Products, School of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;4. Department of Operative Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;5. Department of Community and Preventive Dentistry, School of Dentistry Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;1. Department of Civil Engineering and Architecture, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy;2. Laboratori Nazionali del Sud - INFN, Via S. Sofia, 62, 95125 Catania, Italy;3. Department of Physics and Astronomy, University of Catania, Viale A. Doria, 6, 95125 Catania, Italy;1. Department of Applied Sciences, Punjab Technical University, Kapurthala 144601, India;2. Department of Physics, D.A.V. College, Bathinda 151001, Punjab, India;3. Department of Physics, Kanya Maha Vidyalaya, Jalandhar 144001, India;4. Department of Applied Sciences, Ferozpur College of Engineering and Technology, Ferozshah, Ferozpur 142052, India |
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| Abstract: | Bismuth subgallate (BS) is a hemostatic agent used for soft tissue surgery in otorhinolaryngology and dermatology. Its effect on bone repair has not been studied. The present study undertook a quantitative and qualitative evaluation of post-extraction bone healing in the presence of BS. Under intraperitoneal anesthesia, forty male Wistar rats, 80 ± 5 g body weight, underwent the extraction of both lower first molars. BS was placed in the right post-extraction socket (group E) and the contralateral socket served as control (group C). The animals were killed in groups immediately, 7, 14 and 30 days post-extraction. The mandibles were resected, radiographed and processed for embedding in paraffin. The mesial socket was sectioned along the bucco-lingual axis and stained with hematoxylin-eosin. Total tissue volume and trabecular bone volume of the apical third of the sockets were determined histomorphometrically. At 14 and 30 days post-extraction, group E exhibited bone tissue that resembled that of group C. Histomorphometric analyses showed no statistically significant differences between groups C and E. Bismuth subgallate did not interfere with post-extraction bone healing. Further studies will analyze the effect of this hemostatic agent on bone repair in aniticoagulated rats. |
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