Comparison of different analytical methods used for analyzing SPECT scans of patients with unilateral condylar hyperactivity |
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| Authors: | CP Saridin PGHM Raijmakers S Al Shamma DB Tuinzing AG Becking |
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| Institution: | 1. Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center & Academic Center of Dentistry, Amsterdam, The Netherlands;2. Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands;3. VU University Medical School, Amsterdam, The Netherlands;1. Maxillofacial Department, Hospital del Salvador, Santiago, Chile;2. Hospital San Borja Arriarán, Santiago, Chile;3. Oral and Maxillofacial Surgery, Universidad de Chile, Santiago, Chile;4. Division of Oral and Maxillofacial Surgery, Universidad de La Frontera, Temuco, Chile;5. Center for Biomedical Research, Universidad Autónoma de Chile, Temuco, Chile;6. Maxillofacial Department, Dentistry School, Universidad de La Frontera, Temuco, Chile;7. Maxillofacial Department, Hospital Hernán Henríquez Aravena, Temuco, Chile;1. Surgeon, Oral and Maxillofacial Surgery Department, Hospital Federal do Andaraí, Rio de Janeiro, Brazil;1. Clinical Professor Departments of Oral and Maxillofacial Surgery and Orthodontics, Texas A&M Health Science Center, Baylor College of Dentistry, Baylor University Medical Center, Dallas TX;2. Clinical Assistant Professor, Department of Oral and Maxillofacial Surgery, Center for Advanced Dental Education, Department of Orthodontics, Saint Louis University, St Louis, MO;3. Oral and Maxillofacial Surgeon, Private Practice, Denton, TX;4. Oral and Maxillofacial Surgeon, Private Practice, Louisville, KY;1. Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Emma Childrens'' Hospital, Academic Center for Dentistry Amsterdam, University of Amsterdam, Amsterdam, The Netherlands;2. Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Emma Childrens'' Hospital, Academic Center for Dentistry Amsterdam, University of Amsterdam, Amsterdam, The Netherlands;3. Professor and Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, VU University Medical Center Amsterdam, Amsterdam, The Netherlands;4. Department Head, Department of Functional Anatomy, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Research Institute MOVE, Amsterdam, The Netherlands;6. Professor and Oral and Maxillofacial Surgeon, Department of Oral and Maxillofacial Surgery, Academic Medical Center, Emma Childrens'' Hospital, Academic Center for Dentistry Amsterdam, University of Amsterdam, Amsterdam, The Netherlands;5. Nuclear Medicine Physician, Department of Radiology, Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands;1. Clinical Professor, Department of Oral and Maxillofacial Surgery, Texas A&M University Health Science Center, Baylor College of Dentistry, Baylor University Medical Center, Dallas, TX;2. Former Fellow, Private Practice, Saint Louis, MO. Assistant Professor, Saint Louis University, Department of Orthodontics, MO, Texas A&M University Health Science Center, Baylor College of Dentistry, Baylor University Medical Center, Dallas, TX;3. Former Fellow, Assistant Professor at Department of Oral and Maxillofacial Surgery, UT Dental School, San Antonio, TX, Texas A&M University Health Science Center, Baylor College of Dentistry, Baylor University Medical Center, Dallas, TX |
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| Abstract: | This study aimed to compare different analytical methods and identify the optimal analysis method to distinguish patients with unilateral condylar hyperactivity (UCH) from those with inactive condyles. Single-photon emission computed tomography (SPECT) scans of patients with progressive and nonprogressive mandibular asymmetry (each group, n = 26), were analyzed using the region of interest technique. Sensitivity, specificity and receiver operating characteristic (ROC) curves were calculated for the different analytic methods. The ROC curve illustrates that UCH can be diagnosed significantly better by determining the percentile bone activity in both condyles. The area under the curve (AUC) of the percentile comparison between the affected and contralateral condyles was 0.93 ± 0.04, that for the condyle/clivus ratio was 0.75 ± 0.07 and for the condyle/cervical spine (CS) ratio 0.57 ± 0.08. Sensitivity for the condyle/clivus ratio was 65% and specificity 61%. Sensitivity for the condyle/CS ratio was 85% and specificity 31%. For the percentile difference of the condyles, sensitivity and specificity were 88%. For UCH patients, direct comparison of bone activity between the affected and contralateral condyle in SPECT scans is the analysis method of choice. Comparison of condylar bone activity to reference bone activity does not have additional value in the diagnosis of UCH. |
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