Reduced language lateralization in first-episode schizophrenia: An fMRI index of functional asymmetry |
| |
| Authors: | Maya Bleich-Cohen Talma Hendler Moshe Kotler Rael D. Strous |
| |
| Affiliation: | 1. University of Colorado Boulder, Department of Psychology and Neuroscience, United States;2. University of Colorado Boulder, Center for Neuroscience, United States;3. Texas A&M University, Department of Psychology, United States;4. Northwestern University, Department of Psychology, United States;1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 Wan Ping Nan Road, Shanghai 200030, China;2. Department of Psychiatry, Shanghai Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, Shanghai 200065, China;3. Department of Radiology, Shanghai Rui Jin Hospital, Shanghai Jiao Tong University, 197 Second Rui Jin Road, Shanghai 200025, China;4. Institute of Mental Health, Peking University, 51 North Hua Yuan Road, Beijing 100191, China;5. The Key Laboratory for Mental Health, Ministry of Health, 51 North Hua Yuan Road, Beijing 100191, China;1. Mental Health Institute of the Second Xiangya Hospital, Central South University, National Clinical Research Center on Mental Health Disorders, National Technology Institute on Mental Disorders, Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China;2. Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China;3. Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China;1. Department of Psychiatry, the Second Xiangya Hospital, Central South University, Changsha, China;2. Mental Health Institute of the Second Xiangya Hospital, Central South University, Changsha, China;3. National Clinical Research Center on Mental Disorders, Changsha, China;4. National Technology Institute on Mental Disorders, Changsha, China;5. Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China;6. Henan Key Laboratory of Biological Psychiatry, Henan Mental Hospital, Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China;7. UMass Memorial Medical Center, UMass Medical School, Worcester, USA |
| |
| Abstract: | Patients with schizophrenia exhibit a decrease or loss of normal anatomical brain asymmetry that also extends to functional levels. We applied functional magnetic resonance imaging (fMRI) to investigate language lateralization in patients with schizophrenia during their first episode of illness, thus excluding effects of chronic illness and treatment. Brain regions activated during language tasks of verb generation and passive music listening were explored in 12 first-episode patients with schizophrenia and 17 healthy controls. Regions of interest corresponded to Broca's area in the inferior frontal gyrus (IFG) and Wernicke's area in the superior temporal sulcus (STS). Patients with schizophrenia had significantly smaller lateralization indices in language-related regions than controls. A similar effect was observed in their IFG and STS regions. There was no difference between the groups in the auditory cortex for the music task. Patients with schizophrenia demonstrated greater activation than the controls in temporal regions: the difference was larger in patients with more severe positive symptom subscores. In conclusion, patients with schizophrenia demonstrated loss of normal functional brain asymmetry, as reflected in diminished lateralization of language-related activation in frontal and temporal regions. This phenomenon was already present during their first episode of psychosis, possibly reflecting developmental brain abnormalities of the illness. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
