Regulation and quality control by Lon-dependent proteolysis |
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| Authors: | Laurence Van Melderen Abram Aertsen |
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| Affiliation: | 1. Génétique et Physiologie Bactérienne, Université Libre de Bruxelles, Faculté des Sciences, IBMM-DBM, 12 Rue des Professeurs Jeneer et Brachet, B-6041 Gosselies, Belgium;1. Sorbonne Universités, UPMC Univ Paris 06, UMR 8256, Biological Adaptation and Ageing – IBPS, F-75005 Paris, France;2. CNRS-UMR 8256, F-75005 Paris, France;3. INSERM U1164, F-75005 Paris, France;4. IPREM-LCABIE UMR 5254, 2 rue du président Angot, F-64000 Pau, France;1. Department of Neurology and Chao Family Comprehensive Cancer Center, UC Irvine School of Medicine, 200 S. Manchester Ave., Suite 206, Orange, CA 92868, USA;2. Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center, Los Angeles, CA 90089-0191, USA;3. Division of Molecular & Computational Biology, Department of Biological Sciences, Dornsife College of Letters, Arts, & Sciences, The University of Southern California, Los Angeles, CA 90089-0191, USA;1. Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089-0191, USA;2. Division of Molecular and Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts & Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA;1. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain;2. Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain;3. Cardiovascular Proteomics Laboratory, Department of Vascular Biology, Centro Nacional de Investigaciones Cardiovasculares, 28029 Madrid, Spain;4. Servicio de Anatomía Patológica, Hospital Universitario Central de Asturias, 33006 Oviedo, Spain;5. Area de Fisiología, Departamento de Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain |
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| Abstract: | After their first discovery in Escherichia coli, Lon homologues were found to be widely distributed among prokaryotes to eukaryotes. The ATP-dependent Lon protease belongs to the AAA+ (ATPases associated with a variety of cellular activities) superfamily, and is involved in both general quality control by degrading abnormal proteins and in the specific control of several regulatory proteins. As such, this enzyme has a pivotal role in quality control and cellular physiology. This review focuses on mechanisms of degradation both from the protease and substrate points of view, and discusses the role of Lon in global regulation, stress response and virulence. |
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