Primary epithelial tumors of the lacrimal gland; a retrospective analysis of 22 patients |
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| Authors: | J Snaathorst A Sewnaik D Paridaens RR de Krijger EH van der Meij |
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| Institution: | 1. Department of Oral and Maxillofacial Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands;2. The Rotterdam Eye Hospital, Department of Oculoplastic Surgery, Rotterdam, The Netherlands;3. Departmant of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands;1. Eye Pathology Section, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Denmark;2. Sahlgrenska Cancer Center, Department of Pathology, University of Gothenburg, Sweden;3. Department of Pathology, Rigshospitalet, Copenhagen, Denmark;4. Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark;1. Shiley Eye Institute, Hamilton Glaucoma Center, University of California San Diego, La Jolla, California, USA;2. USC Roski Eye institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA;3. Department of Ophthalmology and Vision Science, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA;1. Department of Laboratory Medicine and Pathobiology, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada;2. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada;1. Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, 702 Rotary Circle, Indianapolis, IN 46202, USA;2. Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital, Beijing, China;3. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA;4. Roudebush Veterans Administration Medical Center, Indianapolis, IN, USA;1. Northern Jiangsu People’s Hospital, Affiliated Hospital to Yangzhou University, Yangzhou, Jiangsu, China;2. Translational Medicine Research Institute, Geneseeq Technology Inc, Toronto, Ontario, Canada;3. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China |
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| Abstract: | This study analyzed the clinical and histopathological aspects, treatment and prognosis of 22 patients with primary epithelial tumors of the lacrimal gland treated in a single institution over 25 years. 191 lacrimal gland lesions retrieved from the archives of the Department of Pathology, Erasmus University Medical Center, were retrospectively reviewed. The clinical and surgical pathology files of 22 primary epithelial neoplasms (16 benign; 6 malignant tumors) were studied. All benign tumors were pleomorphic adenomas; 50% of the malignant neoplasms were adenoid cystic carcinomas. The mean time from complaint to diagnosis was 3 years for benign tumors and 6 months for malignancies. Most benign tumors were treated by local excision; no recurrences occurred. Treatment of malignant tumors varied but generally involved extensive surgery with postoperative radiotherapy. 50% of these patients showed regional and/or distant metastasis. 33% of patients with malignancy died of their disease. Most primary epithelial tumors of the lacrimal gland are pleomorphic adenomas. They have a long duration of symptoms before diagnosis, are treated by limited surgery and recur infrequently. Malignant tumors have a short duration of symptoms, are sometimes mistaken for inflammatory disease, and are, even in case of aggressive surgery, characterized by a high rate of local recurrence and metastasis. |
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