| 急性肝损伤小鼠一氧化氮变化及愈肝胶囊对其影响 |
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| 引用本文： | 程新,谢朝良,汪静,丁爱萍.急性肝损伤小鼠一氧化氮变化及愈肝胶囊对其影响[J].中国中西医结合杂志,2006(Z1). |
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| 作者姓名： | 程新 谢朝良 汪静 丁爱萍 |
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| 作者单位： | [1]中南大学湘雅医学院附二院 [2]四川省泸州医学院 [3]四川省自贡市肿瘤医院 [4]长沙 |
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| 摘 要： | 目的观察急性肝损伤小鼠血清一氧化氮(NO)的变化及愈肝胶囊对NO的影响。方法用四氯化碳按不同时间建立小鼠急性肝损伤模型,用愈肝胶囊治疗,观察小鼠血清NO、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)的变化、肝组织病理组织学改变。结果模型各组血清NO、ALT、AST随造模时间延长逐步升高。愈肝胶囊能显著降低NO、ALT、AST及改善肝脏病理。结论(1)在急性肝损伤小鼠模型中,随造模时间延长NO、ALT、AST逐步升高,肝组织病理损伤逐步加重。(2)愈肝胶囊在降低ALT和AST同时能降低NO水平。
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| 关 键 词： | 愈肝胶囊 肝损伤 肝功能 一氧化氮 |
Changes of Serum Nitric Oxide Level after Acute Hepatic Injury in Mice and the Effect of Yugan Capsule on It |
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| Authors: | CHENG Xin XIE Chao-liang WANG Jing Hepatopathy Institute The Second Hospital Affiliated to Xiangya Medical College Zhongnan University Changsha |
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| Abstract: | Objective To observe the changes of serum nitric oxide(NO)level after acute hepatic injury (AHI)in mice and the effect of Yugan capsule(YC)on it.Methods The mouse AHI model was induced by carbon tetrachloride(CCl_4)at different time points.After treatment with or without YC,serum nitric oxide(NO), anlanine aminotransferase(ALT)and aspartate aminotransferase(AST)were detected,and liver histopathologic injury was observed at different time points after AHI,respectively.Results Serum NO,ALT and AST in the model group escalated significantly with time going,while they decreased and liver histopathologic injury was im- proved in the YC groups.Conclusion The serum levels of NO,ALT and AST increased,and liver histopathologic injury gradually aggravated with time going after CCl_4 injection.Yugan capsule could decrease the levels of ALT, AST and NO. |
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| Keywords: | Yugan capusule hepatic injury hepatic function nitric oxide |
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