狼疮性肾炎患者血清三参数水平变化及意义

目的　探讨白细胞介素 -6(IL -6)、白细胞介素 -8(IL -8)、白细胞介素 -13 (IL -13 )在狼疮性肾炎 (LN)患者中的变化及临床意义。方法　采用酶联免疫吸附法 (ELISA)检测 5 6例LN患者血清IL -6、IL -8、IL -13含量。结果　活动期LN患者血清IL -6、IL -8、IL -13含量显著高于非活动期组与正常对照组 (P <0 0 1) ,非活动期组LN患者血清IL -6、IL -8、IL -13含量与正常对照组比较无显著性差异 (P >0 0 5 ) ,活动期组LN患者血清IL -6、IL -8、IL -13的含量与抗双链DNA滴度、血沉呈显著正相关(P <0 0 1,P <0 0 5 ) ,而与补体C3 、补体C4则呈显著负相关 (P <0 0 1)。结论　IL -6、IL -8、IL -13可能参与了LN的发病过程 ,可作为LN患者狼疮活跃的临床参考指标 ,对于指导治疗及改善预后有重要意义。

The Level Change and Clinical Significance of Serum IL-6,IL-8 and IL-13 in the Patients with Lupus Nephritis

Objective To investigate the level change and clinical significance of serum IL-6, IL-8 and IL-13 in the patients with lupus nephritis(LN). Methods The levels of serum IL-6,IL-8 and IL-13 were measured by enzyme linked immunosorbent assay (ELISA) in 56 patients with LN. Results The levels of serum IL-6,IL-8 and IL-13 in the patients with active LN were significantly higher than those in the patients with non-active LN and the controls, but had no significant difference between the patients with non-active LN and controls. The levels of serum IL-6,IL-8 and IL-13 in the patients with active LN were positively correlated with anti-dsDNA antibody titre and erythrocyte sedimentation rate, but negatively correlated with the serum levels of complements C 3 and C 4. Conclusion IL-6,IL-8 and IL-13 may be involved in the pathogenesis of lupus nephritis, can serve as a clinical reference index for activity of LN, and have important clinical significance in guiding LN therapy and improving LN prognosis.