| 氯氮平治疗难治性精神分裂症血药浓度与临床效应的关系 |
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| 引用本文： | 杨福收,李一鸣,徐建强,郭志华,魏平,吕路线. 氯氮平治疗难治性精神分裂症血药浓度与临床效应的关系[J]. 临床心身疾病杂志, 1997, 0(3) |
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| 作者姓名： | 杨福收 李一鸣 徐建强 郭志华 魏平 吕路线 |
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| 作者单位： | 河南省精神病医院，洛阳市二院，河南省精神病医院，河南省精神病医院，河南省精神病医院，河南省精神病医院 453002，453002，453002，453002，453002 |
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| 摘 要： | 探讨难治性精神分裂症患者服用不同剂量氯氮平后血药浓度与临床疗效的关系。结果发现血药浓度与口服剂量关系未能确定,与8周末BPRS评分无相关性,与TESS评分呈正相关,高剂量组心电图和脑电图异常例数明显高于低剂量组(P<0.05)。
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| 关 键 词： | 氯氮平 难治性精神分裂症 血药浓度 临床效应 |
Relationship Between Serum Concentrations and Clinical Effects of Clozapine in Resistant Schizophrenia |
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| Yang Fushou et al. Relationship Between Serum Concentrations and Clinical Effects of Clozapine in Resistant Schizophrenia[J]. Journal of Clinical Psychosomatic Diseases, 1997, 0(3) |
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| Authors: | Yang Fushou et al |
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| Affiliation: | Yang Fushou et al.The Second Affiliated Hospital of XinXiang Medical College 453002 |
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| Abstract: | The purpose of this study was to discuss the relationship between serum concentrations and clinical effects of clozapine in resistant schizophrenia. The results showed that serum concentrations of clozapine were not correlated with BPRS score at the end of 8th week, and was positively correlated with the TESS score. The numbers of abnormal ECG and EEG were more higher in high dosage group than in the low's. |
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| Keywords: | Clozapine Resistant Schizophrenia Serum concentration clinical effects. |
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