Transfer of nongenetic thermostability from genetically thermostable to genetically thermolabile poliovirus

Summary Adding the genetically thermostablecrⁱ mutant of the Akron strain of type 1 poliovirus to the genetically thermolabile Akronca³⁰ mutant before infection of monkey kidney tissue culture sheets resulted in an average 17-fold increase in the heat-surviving fraction of theca³⁰ virus progeny. Mixing the 2 viruses after infection did not result in any increase. The progenies of at least most of these thermostable transferee particles were thermolabile. By this criterion the transferred thermostability was at least mainly nongenetic.Aided by grant from National Foundation.