| 糖尿病大鼠肾脏一氧化氮系统基因表达的研究 |
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| 引用本文： | 倪连松,吴万龄,盛宏光,杨裕国.糖尿病大鼠肾脏一氧化氮系统基因表达的研究[J].中华糖尿病杂志,2000,8(3):161-163. |
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| 作者姓名： | 倪连松 吴万龄 盛宏光 杨裕国 |
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| 作者单位： | 现在温州医学院附属第一医院内分泌科(倪连松)，上海第二医科大学附属第九人民医院内分泌科!200011(吴万龄，盛宏光，杨裕国) |
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| 摘 要： | 目的 研究糖尿病大鼠肾脏一氧化氮系统基因的表达。方法 观察了１２周ＳＴＺ－糖尿病大鼠肾脏皮质一氧化氮（ＮＯ）含量及一氧化氮合成酶（ＮＯＳ）活力，并应用ＲＴ－ＰＣＲ技术检测了肾脏皮质诱生型一氧化氮合成酶ｍＲＮＡ水平的改变。结果 糖尿病大鼠肾脏皮质ＮＯＳ活性及ｉＮＯＳ ｍＲＮＡ水平明显高于正常对照组（Ｐ〈０．０５），然而ＮＯ含量却反而下降（Ｐ〈０．０５）。结论 糖尿病大鼠肾脏一氧化氮合成障碍，灭活加速
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| 关 键 词： | 糖尿病肾病 一氧化氮 病理 |
A study on the gene expression of nitric oxide system in diabetic kidney |
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| Ni Liansong,Wu Wanling,Sheng Hongguang,et al.A study on the gene expression of nitric oxide system in diabetic kidney[J].Chinese Journal of Diabetes,2000,8(3):161-163. |
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| Authors: | Ni Liansong Wu Wanling Sheng Hongguang |
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| Abstract: | Objective To study on the gene expression of nitric oxide system in diabetic kidney.Methods We have investigated the level of nitric oxide (NO) and the nitric oxide synthase (NOS) activity in the renal cortex of streptozotocin induced diabetic and control rats at the 12 th week.The level of inducible nitric oxide synthase (iNOS) mRNA of renal cortex was also observed by RT PCR.Results The nitric oxide synthase activity and the level of iNOS mRNA were increased in the diabetic rats,however the nitric oxide level showed a significant decrease in contrast to normal group.Conclusion There are impaired production and/or accelerated deactivity of nitric oxide in the renal cortex of diabetic rats. |
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| Keywords: | Diabetic nephropathy Nitric oxide |
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