| 纤维类中药对水丸溶出度影响的试验研究 |
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| 引用本文： | 陈天朝,马兰兰,王小生,秦西林.纤维类中药对水丸溶出度影响的试验研究[J].中国实验方剂学杂志,2010,16(16):21-23. |
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| 作者姓名： | 陈天朝 马兰兰 王小生 秦西林 |
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| 作者单位： | 1. 河南中医学院第一附属医院,郑州,450000
2. 河南中医学院,郑州,450008 |
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| 基金项目： | 河南省教育厅自然科学研究项目 |
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| 摘 要： | 目的:建立纤维类中药含量与水丸溶出度关系的数学模型,考察纤维类中药对水丸溶出度的影响。方法:制备系列水丸,以总黄酮含量为考察指标,测定其溶出度,根据Weibull分布提取溶出参数,用SPSS软件处理数据,拟定非线性数学模型。结果:溶出参数T20,T50的数学模型为y=-3+3/x,y=596-5 984x+27 489x2-41 704x3,水丸处方中纤维类中药的含量与溶出度呈正相关。结论:通过调节处方中纤维类成分的含量可控制水丸的溶出度。
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| 关 键 词： | 水丸 溶出度 纤维类中药 数学模型 |
| 收稿时间： | 2009/6/12 0:00:00 |
Experimental Study on Influence of Dissolution Rate for Traditional Chinese Medicine Contains Cellulose to Water-Paste Pill |
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| CHEN Tian-chao,MA Lan-lan,WANG Xiao-sheng and QIN Xi-lin.Experimental Study on Influence of Dissolution Rate for Traditional Chinese Medicine Contains Cellulose to Water-Paste Pill[J].China Journal of Experimental Traditional Medical Formulae,2010,16(16):21-23. |
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| Authors: | CHEN Tian-chao MA Lan-lan WANG Xiao-sheng and QIN Xi-lin |
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| Institution: | CHEN Tian-chao1,MA Lan-lan2,WANG Xiao-sheng2,QIN Xi-lin2(1.The First Affiliated Hospital of Henan College of Traditional Chinese Medicine,Zhengzhou 450000,2.Henan College of Traditional Chinese Medicine Pharmaceutical Preparations Professional,Zhengzhou 450008) |
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| Abstract: | Objective:To establish mathematical model between the both.Method:Prepare water-paste pills accordingly.Determine its dissolution,and then take the dissolution parameters through distribution model,disposal data with SPSS,finally obtain non-linear mathematical model.Result:For T20,the mathematical model was y =-3 + 3 /x;For T50,the mathematical model was y = 596-5 984x + 27 489x2-41 704x3.A relationship of positive correlation was found between the contents and the dissolution rate of TCM containing cellulo... |
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| Keywords: | water-paste pill dissolution rate TCM containing cellulose mathematical model |
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