Radiosynthesis of [123I]N‐(3‐iodoprop‐(2E)‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

The radiosynthesis of a novel tropane derivative ¹²³I]KUC‐25019, ¹²³I];N‐(3‐iodoprop‐(2E)‐enyl)‐2α‐(imino‐methyl)‐3β‐(3′,4′‐dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the ¹²³I‐labeling synthesis. The no‐carrier‐added ¹²³I‐labeling has about 20% yield, the specific activity of ¹²³I]KUC‐25019 is > 107 GBq/µmol and the radiochemical purity of ¹²³I] KUC‐25019 is >95%. Copyright © 2002 John Wiley & Sons, Ltd.