糖皮质激素治疗海洛因海绵状白质脑病的临床对照研究

目的评价糖皮质激素对海洛因海绵状白质脑病的疗效。方法随机将20名患者分为对照组和治疗组。对照组给予维生素B族药及辅酶Q10治疗,1个月后带药出院;治疗组在上述用药的基础上加用地塞米松20 mg/d,连用10 d后渐减量。对比治疗前、治疗后1个月、半年及1年两组患者的症状改善情况。结果两组患者治疗前、后对比无显著差异(P>0.05)。各组内对比结果显示,治疗后均较治疗前好转(P<0.05)。结论糖皮质激素治疗海洛因海绵状白质脑病无显著疗效,病后1~6个月内恢复较快,而6个月后症状恢复较慢。

Glucocortioid treatment for heroin-induced spongiform leucoencephalopathy: a clinical controlled study

Objective To evaluate the therapeutic effects of the glucocorticoid on heroin-induced spongiform leucoencephalo- pathy. Methods Twenty cases of heroin-induced spongiform leucoencephalopathy were randomly divided into the control group and the treating group with equal number. In the control group, the treatment was constituted by oral administration of vitamin B and coenzyme Q10 in a course of 1 month. In glucocorticoid treatment group, glucocorticoid (20 mg/d) for 10 d were given in addition to vitamin B and coenzyme Q10, and the dose of the glucocorticoid was gradually decreased afterwards. General observation and statistical analysis of function scores were performed in both groups before and 1, 6, 12 months after the treatment respectively. Results No significant difference in function scores was observed between the 2 groups, while the results of observation before and after the treatment were significantly different (P<0.05). The most significant difference occurred when comparing the observations made 1 month and 6 months respectively after treatment (P<0.001). Conclusion Glucocorticoid has no obvious therapeutic effect on heroin-induced spongiform leucoencephalopathy, and rapid clinical recovery occurs within the initial 6 months of the treatment.