| Effect of Astragalus Membranaceus on Ca￣(2＋）Influx and CVB3 RNA Replication in Cultured Neonatal Rat Heart C |
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| 引用本文： | Qi Guo,Tian-Qing Peng,Ying-Zhen Yang,Quan-Bao Gu,Jian-Xing Zhao. Effect of Astragalus Membranaceus on Ca￣(2＋）Influx and CVB3 RNA Replication in Cultured Neonatal Rat Heart C[J]. 中国结合医学杂志, 1996, 2(1): 64-67. DOI: 10.1007/BF02934230 |
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| 作者姓名： | Qi Guo Tian-Qing Peng Ying-Zhen Yang Quan-Bao Gu Jian-Xing Zhao |
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| 作者单位： | GUO Qi (郭棋 ) ; PENG Tian-oing(彭天庆 ); YANG Ying-zhen (杨英珍 )(Shanghai Institute of Cardiovascular Diseases，Zhong Shan Hospital of Shanghai Medical University，Shanghai 200032)GU Quan-bao (顾全保 ) and ZHAO Jian-xing (赵剑星 )(Shanghai Institute of C |
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| 摘 要： | ＥｆｆｅｃｔｏｆＡｓｔｒａｇａｌｕｓＭｅｍｂｒａｎａｃｅｕｓｏｎＣａ￣（２＋）ＩｎｆｌｕｘａｎｄＣＶＢ３ＲＮＡＲｅｐｌｉｃａｔｉｏｎｉｎＣｕｌｔｕｒｅｄＮｅｏｎａｔａｌＲａｔＨｅａｒｔＣｅｌｌｓＩｎｆｅｃｔｅｄｗｉｔｈＣＶＢ３ＧＵＯＱｉ（郭棋）；ＰＥ...
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Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3 |
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| Qi Guo,Tian-Qing Peng,Ying-Zhen Yang,Quan-Bao Gu and Jian-Xing Zhao. Effect of Astragalus Membranaceus on Ca2+ influx and CVB3 RNA replication in cultured neonatal rat heart cells infected with CVB3[J]. Chinese journal of integrative medicine, 1996, 2(1): 64-67. DOI: 10.1007/BF02934230 |
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| Authors: | Qi Guo Tian-Qing Peng Ying-Zhen Yang Quan-Bao Gu Jian-Xing Zhao |
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| Affiliation: | 1. Shanghai Institute of Cardiovascular Diseases, Zhong Shan Hospital of Shanghai Medical University, 200032, Shanghai
2. Shanghai Institute of Cell Biology, Academia Sinica, 200031, Shanghai
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| Abstract: | Here was investigated the effect of Radix Astragalus Membranaceus IAM) on Caz influxacross the myocardial plasma membrane and coxsackie virus B3 ( CVB3 ) -RNA replication in cultured neonatalrat heart cells infected with CVB3 . It was found that the Oa2 intlux could be inhibited signiticantly by AM bothin heart cells intected with CVB3 for 48 hours and in normal control heart cells. In addition. the Caz intluxand the amounts of CVB3-RNA in rnyocytes simultaneously intected with CVB3 and treated with AM for 48hours were statistically decreased compared with that in CVB3-infected contrOI cells. These phenomena sug-gested that AM could exert the effects of decreasing the secondary Ca2 damages, irnproving the abnormalmyocardial electric activity and inhibiting replication of CVB3-RNA in myocardium. Thus, it is a rationalchoice to treat patients with AM in viral myocarditis. |
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| Keywords: | Coxsackievirus B3 viral myocarditis Ca2 influx Radix Astragalus membranaceus |
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