| 黄连水煎剂对未孕大鼠离体子宫平滑肌运动的影响 |
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| 引用本文： | 高宇勤,秦晓民,徐敬东,王磊,鲁彦.黄连水煎剂对未孕大鼠离体子宫平滑肌运动的影响[J].中药药理与临床,2002,18(5):33-35. |
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| 作者姓名： | 高宇勤 秦晓民 徐敬东 王磊 鲁彦 |
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| 作者单位： | 兰州医学院生理教研室,兰州,730000 |
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| 摘 要： | 目的 :探讨黄连水煎剂对未孕大鼠离体子宫平滑肌运动的影响。方法 :利用BL 3 10智能型生物信号显示与处理系统记录平滑肌条的等长收缩活动。结果 :黄连水煎剂能明显延长收缩波持续时间 ,增加收缩波面积且有显著正相剂量效应关系 ,还可增加收缩波的振幅但无剂量效应关系 ,黄连水煎剂的这作用可被异搏定 (L型电压依赖性Ca2 通道阻断剂 )所阻断。结论 :黄连水煎剂在体外可增强子宫平滑肌的收缩 ,该作用是通过L型钙通道而发挥的。
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| 关 键 词： | 黄连水煎剂 离体子宫平滑肌 |
The action of Coptis root decoction on contractile activity of isolated uterine smooth muscle strips from rats |
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| Gao Yuqin,Qing Xiaomin,Xu Jindong,Wang Lei,Lou Yan.The action of Coptis root decoction on contractile activity of isolated uterine smooth muscle strips from rats[J].Pharmacology and Clinics of Chinese Materia Medica,2002,18(5):33-35. |
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| Authors: | Gao Yuqin Qing Xiaomin Xu Jindong Wang Lei Lou Yan |
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| Institution: | Lanzhou Medical College Lanzhou 730000 |
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| Abstract: | Objective: To study the effect of coptis root decoction on contractile activity of isolate uterine smooth muscle strips in nonfertile rats. Methods: BL-310 was used to record the isometric contraction of uterine smooth muscle strips. Results: Coptis root decoction can dose dependently extend the average area of contraction waves, which can be blocked by verapamil. Conclusion: (1) Coptis root decoction can increase the contraction of isolated uterine smooth muscle strips in nonfertile rats. (2) The action of Coptis root decoction is mediated via voltage dependent Ca~ 2 channel L. |
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| Keywords: | Coptis root decoction uterine smooth muscle |
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