冠心病患者血清一氧化氮α-颗粒膜蛋白的含量及临床意义

目的　探讨一氧化氮 (NO)、α 颗粒膜蛋白 (GMP 14 0 )在冠心病 (CHD)发病机制中的作用。方法　采用Griess比色法 ,酶联免疫吸附试验检测了 4 0例冠心病患者 (其中 2 2例不稳定型心绞痛患者 ,18例稳定型心绞痛患者 )血清中NO、GMP 14 0的水平。结果　①冠心病组血清NO水平显著低于正常对照组 (P <0 0 1) ,GMP 14 0水平显著高于正常对照组 (P <0 0 1)。②不稳定型心绞痛组NO水平显著低于稳定型心绞痛组 (P <0 0 1) ,GMP 14 0水平显著高于稳定型心绞痛组 (P <0 0 1)。③冠心病组血清NO与GMP 14 0水平间呈显著负相关 (r =- 0 70 5 ,P <0 0 1)。结论　血清NO、GMP 14 0水平在冠心病的发生、发展中起着重要的作用 ,动态检测患者血清NO、GMP 14 0的水平 ,有助于临床判断病情和观察疗效

Serum levels of nitric oxide and alpha-granule membrane protein in patients with coronary heart disease and their clinical significance

Objective To detect the effect and clinical significance of the serum level changes of nitric oxide (NO) and alpha granule membrane protein (GMP 140)in patients with coronary heart disease (CHD) Methods The serum levels of NO and GMP 140 were measured in 40 patients with CHD (22 patients with unstable angina,18 patients with stable angina) and 45 control subjects by Griess calorimetric method and enzyme linked immunosorbent assay Results ①Serum levels of NO were significantly lower in patients with CHD than those in control group ( P <0 01) ②Serum levels of NO were significantly lower in patients with unstable angina than those in stable angina,serum levels of GMP 140 were significantly higher than those in stable angina ③Negative correlation was present between the NO and GMP 140 ( P <0 01) Conclusion The result shows that serum levels of NO and GMP 140 play an important role in the happening and development of CHD;measuring the serum of NO and GMP 140 is helpful for indicating the severity of CHD and its therapeutic effect