Antigenicity and immunogenicity of a synthetic oligosaccharide-protein conjugate vaccine against Haemophilus influenzae type b |
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Authors: | Fernández-Santana V Cardoso Félix Rodriguez Arlene Carmenate Tania Peña Luis Valdés Yuri Hardy Eugenio Mawas Fatme Heynngnezz Lazaro Rodríguez Maria C Figueroa Ignacio Chang Janoi Toledo Maria E Musacchio Alexis Hernández Ibis Izquierdo Mabel Cosme Karelia Roy Rene Verez-Bencomo V |
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Affiliation: | Center for the Study of Synthetic Antigens, Facultad de Química, Universidad de La Habana, Havana, Cuba 10400. violeta@fq.uh.cu. |
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Abstract: | Polysaccharide-protein conjugates as vaccines have proven to be very effective in preventing Haemophilus influenzae type b infections in industrialized countries. However, cost-effective technologies need to be developed for increasing the availability of anti-H. influenzae type b vaccines in countries from the developing world. Consequently, vaccine production with partially synthetic antigens is a desirable goal for many reasons. They may be rigidly controlled for purity and effectiveness while at the same time being cheap enough that they may be made universally available. We describe here the antigenicity and immunogenicity of several H. influenzae type b synthetic oligosaccharide-protein conjugates in laboratory animals. The serum of H. influenzae type b-immunized animals recognized our synthetic H. influenzae type b antigens to the same extent as the native bacterial capsular polysaccharide. Compared to the anti-H. influenzae type b vaccine employed, these synthetic versions induced similar antibody response patterns in terms of titer, specificity, and functional capacity. The further development of synthetic vaccines will meet urgent needs in the less prosperous parts of the world and remains our major goal. |
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