Gadoteridol dose dependence in MR imaging of a liver abscess model |
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Authors: | Val M. Runge John E. Kirsch Cecil Woolfolk Mitchell A. Brack Robert A. Garneau |
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Abstract: | A necrotic liver abscess model was studied with magnetic resonance (MR) imaging at 1.5 T before and after intravenous administration of gadoteridol at doses of 0.1, 0.25, and 0.5 mmol/kg in 24 rabbits. Enhancement characteristics and lesion delineation were assessed with both breath-hold and non-breath-hold imaging techniques. Lesion delineation, as assessed both by signal intensity measurements and evaluations by two image readers blinded to imaging technique, was greatest on high-dose (0.5 mmol/kg) breath-hold images. Lesion rim enhancement was seen consistently only on postcontrast images obtained at a dose of 0.5 mmol/kg and progressed with time after injection of contrast material. |
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Keywords: | Contrast enhancement Contrast media, experimental studies Gadolinium Liver, infection, 761.12143, 761.21 Liver, MR, 761.12143 Liver, necrosis, 761.12143, 761.21 |
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