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Antiprotozoal activities of Centipeda minima |
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| Authors: | H W Yu C W Wright Y Cai S L Yang J D Phillipson G C Kirby D C Warhurst |
| Abstract: | In vitro activity against Giardia intestinalis was used for bioassay-guided fractionation of crude extracts from C. minima. The sesquiterpene lactone, brevilin A was isolated and found to have antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). Three flavonoids, quercetin, quercetin 3-methyl ether and kaempferol 7-glucosylrhamnoside were also isolated. |
| Keywords: | Brevilin A sesquiterpene lactones Entamoeba histolytica Giardia intestinalis Plasmodium falciparum |