Pharmacological activity of the extracts of two Satureja obovata varieties on isolated smooth muscle preparations |
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Authors: | V. R. S nchez de Rojas,T. Ortega,A. Villar |
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Affiliation: | V. R. Sánchez de Rojas,T. Ortega,A. Villar |
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Abstract: | Aqueous extracts of two varieties of Satureja obovata Lag. subsp. obovata: var. valentina and var. obovata, exhibited a dose-dependent inhibitory effect on the contractions induced by acetylcholine (Ach) (3.4 × 10?8?6.8 × 10?5M) and CaCl2 (2 × 10?4?1.28 ? 10?2M) in rat duodenum and by noradrenaline (NA) (10?9?5.12 × 10?7 M) and CaCl2 (2 × 10?4?1.28 × 10?2 M) in rat aorta. The extracts also produced relaxant effects in both tissue preparations precontracted with K+ (75 mM) and in rat aorta precontracted with NA (10?6 M). Vasodilatory effects of the two extracts were attenuated when the endothelium was removed. The inhibitory effects of var. valentina were stronger. These results indicated a smooth muscle relaxant effect that could account for the use of these extracts in traditional medicine. |
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Keywords: | Satureja obovata smooth muscle relaxation rat duodenum rat aorta endothelial influence pharmacological effects |
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