| MicroRNA与胆管癌研究进展 |
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| 引用本文： | 陈强,李文岗. MicroRNA与胆管癌研究进展[J]. 世界华人消化杂志, 2010, 18(6) |
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| 作者姓名： | 陈强 李文岗 |
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| 作者单位： | 福建医科大学附属厦门第一医院肝胆胰血管外科,福建省厦门市,316003;福建医科大学附属厦门第一医院肝胆胰血管外科,福建省厦门市,316003 |
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| 基金项目： | 福建省自然科学基金资助项目 |
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| 摘 要： | MicroRNA(miRNA)是一类新发现的、非编码的、大小约为22个核苷酸,参与转录后基因调控的RNA,广泛存在于动植物中.研究已经证实,miRNA在细胞的增殖、凋亡、分化、个体发育等方面发挥着巨大作用,另9kmiRNA与肿瘤的发生和发展密切相关,发挥着癌基因或抑癌基因的作用.本文主要介绍miRNA的产生、作用机制、生物功能以及在胆管癌的发生和发展中的作用.
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| 关 键 词： | MicroRNA 癌基因 抑癌基因 胆管癌 |
Advances in understanding the relationship between microRNAs and cholangiocarcinoma |
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| Qiang Chen,Wen-Gang Li. Advances in understanding the relationship between microRNAs and cholangiocarcinoma[J]. World Chinese Journal of Digestology, 2010, 18(6) |
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| Authors: | Qiang Chen Wen-Gang Li |
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| Affiliation: | Qiang Chen,Wen-Gang Li,Department of Hepato- Biliary-Pancreatic-Vascular Surgery,the First Hospital of Xiamen Affi liated to the Fujian Medical University,Xiamen 316003,Fujian Province,China |
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| Abstract: | MicroRNAs (miRNAs) are a class of short non-coding RNAs widely distributed in plants and animals. They can inhibit the expression of protein-coding genes by binding to the 3' UTR of mRNAs and inducing either translational repression or mRNA degradation. It has been demonstrated that miRNAs play important roles in regulating cell proliferation, apoptosis and differentiation. In addition, miRNAs can function as oncogenes or tumor suppressor genes and are therefore closely associated with oncogenesis. This rev... |
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| Keywords: | MicroRNA |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
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