重组红细胞生成素治疗早产儿贫血36例的临床分析

目的探讨重组红细胞生成素治疗早产儿贫血的临床疗效。方法选择2010年1月至2011年12月收治的胎龄不小于36周的早产儿72例,随机分成两组,各36例。对照组给予每日口服维生素C和E各25 mg、铁剂5 mg/kg等常规治疗,治疗组在此基础上于出生后的第1周给予重组红细胞生成素600 IU/kg皮下注射,每周3次,隔日1次,共6周。比较两组早产儿的输血率、体重增长情况及血常规变化。结果治疗组输血率(16.67%)低于对照组(47.22%,P<0.05);体重增长速率显著高于对照组(P<0.05);用药后血红蛋白、红细胞压积、网织红细胞显著高于对照组(P<0.05);血清铁蛋白水平显著低于对照组(P<0.05)。结论重组红细胞生成素可有效防治早产儿贫血,减少输血次数,快速增长早产儿体重,安全性高,值得临床推广。

Application Analysis on Recombinant Erythropoietin in Treatment of Prematurity Anemia

Objective To study the clinical efficacy of recombinant erythropoietin for the treatment of anemia in premature in- fants. Methods 72 premature infants with the gestational age not less than 36 weeks treated in our hospital from January 2010 to De- cember 2011 were randomly divided into two groups,36 cases in each group. The control group was given the routine therapy of oral vitamin C and vitamin E, each 25 mg daily, and ferralia 5mg/kg, while on this basis, the treatment group was given recombinant ery- thropoietin 600 IU/kg by subcutaneous injection,once every other day,3 times per week for 6 weeks. The blood transfusion rate,weight gain and the change of blood routine were compared between the two groups of preterm infants. Results The blood transfusion rate was 16.67% in the treatment group,which was lower than 47.22% in the control group,the difference was statistically significant （P 〈 0. 05）;the weight growth rate of the treatment group was significantly higher than that of the control group （P 〈 0. 05）;hemoglobin （Hb）,hematocrit （Hct） and reticuloeytes （Ret） after medication in the treatment group were significantly higher than those in the con- trol group,the difference showing statistical significance （P 〈 0.05）;the serum ferritin （SF） level in the treatment group was signifi- cantly lower than that in the control group with statistical difference between the two groups （P 〈 0. 05）. Conclusion Recombinant erythropoietin can effectively prevent and treat anemia in premature infants, reduce the frequency of blood transfusion and rapidly in- crease the body weight of premature infants with high safety,which is worthy of being popularized in clinical practice.