五麦党黄口服液对辐射损伤小鼠防护作用的初步研究

目的研究抗辐射复方中药五麦党黄口服液(WMDH)的辐射防护作用。方法将小鼠分为5组,即正常对照组、模型组、3个给药剂量组,连续给药14 d,末次给药后3 h采用60Coγ射线一次性全身照射(7.5 Gy),于照射后记录各给药组存活时间及30 d存活率;另分组及给药剂量同前,连续给药14 d,采用60Coγ射线一次性全身照射(3.0 Gy),测定各给药组动物外周血白细胞数、胸腺、脾脏指数。结果WMDH口服液可显著延长受照射小鼠的存活时间,升高外周血白细胞数、胸腺指数、脾脏指数。结论WMDH口服液对试验小鼠核辐射损伤具有明显的保护作用,值得进一步研究和开发。

Preliminary Study of Protection Effects of Wumaidanghuang Oral Liquid on Radiation Damage Mice

Objective To study the of radioprotection effects of Wumaidanghuang （WMDH） Oral Liquid. Methods Mice were divided into 5 groups including the healthy control, model group and 3 doses groups, and were given medicine for continuous 14 d. At 3 h after last dose administration, the model group and three experimental groups were performed the once systemic irradiation with 7.5 Gy ^60Coγ rays. The survival time and the 30 d survival rate were recorded in various doses groups. Another group was treated with the same dose of medicine for continuous 14 d. 3.0 Gy ^60Coγ rays was adopted for once systemic irradiation. Peripheral blood WBC, the spleen and thymus indexes were determined in various doses groups. Results WMDH Oral Liquid could effectively extend the survival time, increase peripheral blood WBC and the spleen and thymus indexes in the irradiated mice. Conclusion WMDH Oral Liquid has obvious radioprotection effect on the mice radiation damage, which deserves to be further researched and developed.