埃索美拉唑和奥美拉唑治疗反流性食管炎的疗效对比

目的对比埃索美拉唑和奥美拉唑治疗反流性食管炎的临床疗效。方法选择医院收治的反流性食管炎患者90例,随机分成两组,对照组42例于每日早餐前30 min给予口服40 mg奥美拉唑,每日1次;治疗组48例于每日早餐前30 min给予口服40 mg埃索美拉唑,每日1次。两组疗程均为8周。疗程结束后观察两组患者的临床疗效、治疗前后临床症状评分、胃镜下食管炎改善情况及不良反应。结果总有效率对照组为76.19%,治疗组为91.67%,两组差异有统计学意义(P<0.05);两组患者治疗后症状评分与治疗前相比均有明显下降,治疗组下降较对照组明显,差异有统计学意义(P<0.05);两组患者治疗后胃镜下食管炎均有所改善,治疗组显著优于对照组,差异有统计学意义(P<0.05);对照组出现3例头痛,2例恶心,4例腹泻,2例食欲减退;治疗组出现4例头痛,1例恶心,5例腹泻,症状轻微,均不影响继续治疗,停药后症状消失;两组治疗前后检查肝肾功能、血尿便常规均无异常。结论埃索美拉唑和奥美拉唑治疗反流性食管炎均有显著疗效,可有效缓解患者的临床症状,不良反应少,但埃索美拉唑临床疗效明显优于奥美拉唑,是治疗反流性食管炎安全有效的药物,值得临床推广。

Efficacy Comparison of Esomeprazole and Omeprazole in Treatment of Reflux Esophagitis

Objective To compare the effects of esomeprazole and omeprazole in the treatment of reflux esophagitis. Methods Ninety cases of reflux esophagitis treated in this hospital were collected randomly divided into two groups. The control group （42 cases） was given oral omeprazole 40 mg,once daily at 30 rain before breakfast,while the treatment group （48 cases） was given oral esomeprazole 40 rag,once daily at 30 min before breakfast. The two groups were treated for 8 weeks. The clinical efficacy,clinical symptom scores be- fore and after treatment,endoscopic esophagitis improvement situation and the adverse reactions were observed and compared between the two groups. Results The total effective rate was 76. 19% in the control group and 91.67% in the treatment group,the difference be- tween the two groups showing statistical significance （P 〈 0.05）. The symptom scores after treatment were obviously decreased com- pared with the before treatment,but the decrease in the treatment group was more significant than that in the control group with statis- tical difference （P 〈 0. 05）. Endoscopic esophagitis after treatment was improved, but the treatment group was significantly superior to the control group,the difference between the two groups was statistically significant（P 〈 0.05）.The treatment group had 1 case of nausea and vomiting, 1 case of abdominal pain,while the control group had 3 cases of headache, 1 case of nausea and 5 cases of diar- rhea. The symptoms were mild, did not affect the continued treatment, and disappeared after medication discontinuation. The liver and kidney functions, routine of blood, urine and stool before and after treatment showed no abnormality. Conclusion Esomeprazole and omeprazole have the significant effect in the treatment of reflux esophagitis, can effectively alleviate the clinical symptoms with less ad- verse reactions. But esomeprazole is superior to omeprazole in the clinical efficacy, and a safe and effective drug for treating reflux esophagitis,which deserves to be popularized in clinic.