度洛西汀与西酞普兰治疗抑郁症的最小成本分析

目的评价度洛西汀与西酞普兰治疗抑郁症的经济效果和安全性,以利临床合理用药。方法将50例抑郁症患者随机分为度洛西汀组、西酞普兰组,分别给予度洛西汀、西酞普兰治疗6周,比较两组疗效和不良反应,并应用药物经济学最小成本分析法进行评价。结果度洛西汀组和西酞普兰组总有效率分别为96.00%和92.00%,2组间疗效差异无统计学意义(P>0.05),成本分别为1 030.88元和1 092.09元,成本/效果(C/E)分别为1 073.83和1 187.05,度洛西汀组的不良反应率较西酞普兰组低。结论度洛西汀和西酞普兰治疗抑郁症疗效相当,度洛西汀治疗成本与不良反应发生率均较低,是治疗抑郁症较佳治疗方案。

Analysis on Minimum Cost of Duloxetine and Citalopram in Treating Depression

Objective To evaluate the economic effects and safety of duloxetine and citalopram in the treatment of depression to provide the guidance for clinical rational drug use.Methods Fifty patients with depression were randomly divided into the duloxetine group and the citalopram group,and treated by duloxetine and citalopram for 6 weeks,respectively.The curative efficacies and adverse reactions were compared between the two groups.The evaluation was performed by the pharmacoeconomics cost minimization analysis method.Results The total effective rates in the duloxetine group and the citalopram group were 96.00%and 92.00%respectively,without statistical difference between the two groups existed（P 0.05）;the costs were 1 030.88 Yuan and 1 092.09 Yuan,cost/effect ratios（C/E） were 1 073.83 and 1 187.05 respectively.The rate of adverse reactions in the duloxetine group was lower than that in the citalopram group.Conclusion The effects of duloxetine and and citalopram in the treatment of depression are equivalent.Duloxetine has the lower cost and is a better therapeutic scheme for the treatment of depression.