乌司他丁治疗胰腺炎120例

目的观察乌司他丁治疗胰腺炎的疗效及不良反应。方法选择2007年6月至2012年6月收治的胰腺炎患者237例,随机分成两组,对照组117例给予一般常规治疗,治疗组120例在常规治疗基础上给予乌司他丁静脉滴注,比较两组患者血尿淀粉酶恢复时间、临床症状缓解时间及疗效,观察不良反应发生情况。结果对照组总有效率为82.05%,治疗组总有效率为94.17%,两组比较差异有统计学意义(P<0.05);治疗组临床症状缓解时间和血尿淀粉酶恢复时间均显著短于对照组(P<0.05);对照组发生25例胃肠道反应,治疗组仅发生4例胃肠道反应,治疗组不良反应发生率显著低于对照组(P<0.05)。结论乌司他丁治疗胰腺炎疗效显著,且不良反应较少,值得临床推广。

Ulinastatin for Treating 120 Cases of Pancreatitis

Objective To observe the clinical efficacy and adverse reactions of ulinastatin for the treatment the pancreatitis.Methods 237 cases of pancreatitis treated in our hospital from June 2007 to June 2012 were randomly divided into the two groups.The control group（117 cases） received the conventional treatment,while the treatment group（120 cases） was given the intravenous injection of ulinastatin based on the conventional treatment of the control group.The clinical efficacy,clinical symptoms alleviation time and urine amylase recovery time were compared between two groups,and the occurrence situation of adverse reactions was observed.Results The total effective rate was 82.05%in the control group and 94.17%in the treatment group,the difference between them was statistically significant（P 〈0.0）.The clinical symptoms alleviation time and the recovery time of blood and urine amylase in the treatment group were significantly shorter than those in the control group,the difference between the two groups had statistical significance（P 〈0.0）.25 cases of gastrointestinal reactions occurred in the controlt group,but only 4 cases of gastrointestinal reactions were found in the treatment group,which the treatment group was significantly less than that in the control group（P 〈0.0）.Conclusion Ulinastatin has significantly efficacy and less adverse reaction for the treatment of pancreatitis,which is worth being promoted in clinical practice.