Controlled release of diphosphonates from synthetic polymers to inhibit calcification |
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| Authors: | G Golomb |
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| Institution: | Department of Pharmacy, School of Pharmacy, Hebrew University of Jerusalem, Israel. |
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| Abstract: | Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and evaluation of controlled-release drug delivery system to inhibit bioprosthetic heart valve calcification is reviewed. |
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