胃炎灵胶囊对慢性萎缩性胃炎模型大鼠氧化-抗氧化平衡的影响

[目的]观察胃炎灵胶囊对慢性萎缩性胃炎(CAG)模型大鼠氧化-抗氧化平衡的影响。[方法]设立空白对照组,并采用综合法复制CAG动物模型32只,随机分为4组,即模型组、胃炎灵大剂量组、胃炎灵小剂量组、维酶素组,每组8只。治疗后分别对各组大鼠胃组织谷胱甘肽-过氧化物酶(GSH-Px)、一氧化氮(NO),胃组织及血清超氧化物歧化酶(SOD)活性、丙二醛(MDA)水平进行检测。[结果]与空白组比较,模型组大鼠胃组织GSH-Px、SOD活性下降(P<0.01),MDA、NO水平升高(P<0.01);血清SOD活性下降(P<0.01),MDA水平升高(P<0.01);与模型组比较,胃炎灵胶囊可提高胃组织GSH-Px、SOD活性(P<0.05,<0.01),降低MDA、NO水平(P<0.01,<0.05),提高血清SOD活性(P<0.05),降低MDA水平(P<0.05),且以胃炎灵胶囊大剂量组作用显著。[结论]胃炎灵胶囊具有提高抗氧化酶活性,减轻自由基损伤和抑制脂质过氧化物反应的作用。

Effect of Weiyanling capsule on banlance of oxidation-antioxidation system of chronic atrophic gastritis in rats

[Objective]To study the effect of Weiyanlin capsule(WYL)on banlance of oxidation-antioxidation system of chronic atrophic gastritis in rats.[Methods]Normal group was established as control.Thirty two models of chronic atrophic gastritis were established with synthetic method.The model rats were divided into four groups randomly: model group,high dose of WYL,low dose of WYL and Weimeisu group.The activities of GSH-Px,SOD,content of MDA,NO in gastric tissue,activity of SOD and content of MDA in blood serum were observed.[Results] In successful model group,activity of GSH-Px,SOD in gastric tissue were much lower than those of normal group(P<0.01),content of MDA,NO in gastric tissue were much higher than those of normal group(P<0.01),activity of SOD was much lower than that of normal group(P<0.01)and content of MDA in blood serum was much higher than that of normal group(P<0.01).Compared with the model group,WYL could increase activity of GSH-Px,SOD(P<0.05,P<0.01) and decrease content of MDA and NO(P<0.01;P<0.05) in gastric tissue,increase activity of SOD(P<0.05) and decrease content of MDA and NO(P<0.05) in blood serum significantly.[Conclusion ]WYL can elevate antioxidation enzyme activity,lessen oxygen free radical impairment and inhibit lipid peroxidation.