久坐对男性精液质量的影响

  目的   探究男性静坐时长与主要精液质量参数的相关性。  方法   采用横断面研究方法，招募2017 — 2019年在深圳市某医院生殖中心进行生育咨询的4 532名男性进行问卷调查，采用计算机辅助精液分析设备检测精液质量常规参数（精子总数、精子浓度、总活动率、前向运动率），采用二元logistic回归模型分析静坐时长与精液质量参数间的关系。  结果  精子前向运动率：与静坐时长 < 4 h/d组[（55.29 ± 19.15）%]相比，静坐时长 ≥ 8 h/d组[（53.18 ± 19.59 %）]较低，差异有统计学意义（F = 2.96，P < 0.05）；精子总活动率：与静坐时长4 h/d ～ 组[（66.57 ± 19.50 %）]相比，静坐时长 ≥ 8 h/d组（64.30 ± 20.16 %）较低，差异有统计学意义（F = 3.19，P < 0.05）。logistic回归结果显示，未校正混杂因素时，静坐时长 ≥ 8 h/d组精子前向运动率降低的风险[OR（95 %CI）]是 < 4 h/d组的1.28倍（1.02～1.60）；校正混杂因素后,静坐时长 ≥ 8 h/d组仍与精子前向运动率的下降风险增加有关（P < 0.05）。  结论   久坐（ ≥ 8 h/d）是男性精子前向运动率下降的风险因素。

European association of urology guidelines on male infertility: the 2012 update

  Objective   To investigate the relationship between semen quality and sedentary time.   Methods   A cross-sectional survey was conducted among 4 532 men (aged 18 – 60 years) seeking fertility consultation at a reproductive center of a hospital in Shenzhen city from March 2017 through May 2019. Questionnaire interview and semen sampling were carried out among the participants. Routine indicators of semen quality were determined with a computer assisted semen analysis system (CASA) and the relationship between sedentary time and semen quality indicators was assessed with binary logistic regression analysis.   Results  In comparison to those in the participants reporting the sedentary time of less than 4 hours per day, significantly lower sperm progressive motility rate (53.18 ± 19.59% vs. 55.29±19.15%, F = 2.96; P < 0.05) and total sperm motility rate (64.30 ± 20.16% vs. 66.57 ± 19.50%, F = 3.19; P < 0.05) were detected in the men reporting the sedentary time of 8 hours and above per day. The results of logistic regression analysis showed that compared to those with the sedentary time of less than 4 hours per day, the participants with the sedentary time of 8 hours and above per day were at a significantly increased risk of having a reduced sperm progressive motility (odds ratio = 1.29, 95% confidence interval: 1.03 – 1.62) after adjusting for age, body mass index, days of abstinence, smoking, alcohol drinking, and time of physical activity.   Conclusion  Prolonged sedentary time (≥ 8 h/day) is a risk factor for decreased sperm progressive motility in adult men.