绞股蓝皂苷治疗肝病的研究进展

肝脏疾病影响着全球数亿人口的健康问题。在大多数发达国家，由于疾病的预防、诊断及治疗方面的进步，病毒性肝炎的发病率正在逐年下降。但人们生活水平的提高，使得包括非酒精性脂肪性肝病和酒精性肝病在内的代谢性肝病的发病率不断上升，导致终末期肝病的增加。绞股蓝作为传统中药，临床用药历史悠久，安全性高，其主要药效成分绞股蓝皂苷被证实在多种肝脏疾病的治疗中疗效显著。通过对绞股蓝皂苷治疗肝病的药效及机制的研究进展进行概述，以期为绞股蓝的深入基础研究和临床应用拓展提供参考。

Research Progress of Gypenosides in the Treatment of Liver Disease

Liver diseases affect hundreds of millions of people worldwide. In most developed countries, the incidence of viral hepatitis is waning as a result of modern advances in disease prevention, diagnosis, and treatment. However, with the improvement of the living standards, the prevalence of metabolic liver diseases including non-alcoholic fatty liver disease and alcohol-related liver disease is rising, ultimately leading to more cases of end-stage liver diseases. Gynostemma pentaphyllum, a traditional Chinese medicine, has a long history of clinical use and high safety. As its main medicinal ingredient, gypenosides have been proved to be effective in the treatment of various liver diseases. In this paper, relevant literature reports in recent years were reviewed to summarize the progress of research on the efficacy and mechanism of gypenosides in treating liver diseases, aiming to provide reference for further basic research and clinical application of gypenosides.