泮托拉唑静脉滴注治疗急性上消化道出血的疗效

目的 :观察静脉滴注泮托拉唑治疗急性上消化道出血的疗效。方法 :将 70例病人分为 2组 :泮托拉唑治疗组 4 0例 ,静脉滴注泮托拉唑 4 0mg ,q 12h ,持续 2～ 3d ,出血停止后均予泮托拉唑胶囊4 0mg ,po ,qd维持。雷尼替丁对照组 30例 ,静脉滴注雷尼替丁 15 0～ 2 0 0mg ,q 12h ,持续 2～ 3d ,出血停止后均予以雷尼替丁 30 0mg ,po ,qd维持。结果 :泮托拉唑治疗组有效率 92 % ,止血时间 (1.6±0 .5 )d ,再出血率 3% ,明显优于雷尼替丁对照组分别为 6 7% ,(2 .5± 0 .6 )d和 2 0 % ],均P <0 .0 5。结论 :静脉滴注泮托拉唑是治疗急性上消化道出血有效、安全的药物 ,尤其适用于中、重度出血的病人

Effect of pantoprazole intravenous drip for therapy of acute upper gastrointestinal hemorrhage

AIM: To observe the effect of pantoprazole for therapy of acute upper gastrointestinal hemorrhage. METHODS: Seventy patients were randomly divided into two groups. Forty patients of pantoprazole therpy group (M 33,F 7;age 41 a± s 13 a) received pantoprazole 40 mg, iv, gtt, q 12 h. persisting for 2 3 d. With pantoprezole capsule of 40 mg·d -1 to persist after hemorrhage stopped. Ranitidine control group (M 25,F 5;age 43 a±14 a) received ranitidine 150-200 mg, iv, gtt, q 12 h, persisting for 2-3 d. With ranitidine capsule of 300 mg·d -1 to persist after hemorrhage stopped. RESULTS: Effective rate of pantoprazole therpy group was 92%. Hemostasia times were (1.6±0.5) d and re hemorrhage rate was 3%. The effective rate and hemstasia times and re hemorrhage rate of pantoprazole group was significantly better than ranitidine group effective rate of 67%, hemstasia times of (2.5 ±0.6) d and re hemorrhage rate of 20%]. CONCLUSION: Pantoprazole intravenous drip for therapy the patients of actue upper gastrointestinal hemorrhage is effective and safe, especially adapt to middle and heavy patients of upper gastrointestinal hemorrhage.