| 大黄属药用植物抗HIV-1活性的谱效关系研究 |
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| 引用本文： | 马培,张鑫瑶,许利嘉,王哲,肖培根.大黄属药用植物抗HIV-1活性的谱效关系研究[J].中国中药杂志,2013,38(15):2434-2437. |
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| 作者姓名： | 马培 张鑫瑶 许利嘉 王哲 肖培根 |
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| 作者单位： | 中国医学科学院北京协和医学院药用植物研究所,中草药物质基础与资源利用教育部重点实验室,北京100193 |
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| 基金项目： | 国家"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(2008ZX10005-004) |
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| 摘 要： | 目的:分析大黄属药用植物的超高效液相色谱法(UPLC)特征图谱与抗HIV-1活性之间的相互关系.方法:采用HIV-1逆转录酶相关的核糖核酸酶H活性测定检测了大黄属16种22个样品的抗HIV-1活性;同时测定了22个样品的UPLC特征图谱;运用数理统计方法研究谱效相关性;并采用UPLC-TOF-MS/MS'指认样品主要成分峰.结果:藏边大黄、苞叶大黄和河套大黄提取物有较好的抗HIV-1活性.谱效相关性研究表明4.74,7.99,21.18 min色谱峰与活性有一定相关性.结论:通过谱效研究,推测了有抗HIV-1活性的大黄属药用植物及其活性组分,为大黄属植物深层次的研究开发奠定了基础.
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| 关 键 词： | 大黄 特征图谱 抗HIV-1活性 谱效关系 |
| 收稿时间： | 7/2/2013 12:00:00 AM |
Spectrum-effect relationship between anti-HIV 1 activities and ultra- performance liquid chromatography fingerprints of Rheum species |
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| MA Pei,ZHANG Xin-yao,XU Li-ji,WANG Zhe and XIAO Pei-gen.Spectrum-effect relationship between anti-HIV 1 activities and ultra- performance liquid chromatography fingerprints of Rheum species[J].China Journal of Chinese Materia Medica,2013,38(15):2434-2437. |
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| Authors: | MA Pei ZHANG Xin-yao XU Li-ji WANG Zhe and XIAO Pei-gen |
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| Institution: | Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China;Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China;Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China;Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China;Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Medicinal Plant Development, Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China |
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| Abstract: | |
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| Keywords: | Rheum species chromatographic fingerprint anti-HIV 1 activity spectrum-effect relationship |
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