Increased procollagen alpha1(I) mRNA expression by dermal fibroblasts in melorheostosis |
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| Authors: | Endo H Katsumi A Kuroda K Utani A Moriya H Shinkai H |
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| Affiliation: | Department of Clinical Biology of Extracellular Matrix, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. chw92121@syd.odn.ne.jp |
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| Abstract: | We report a patient with melorheostosis in whom increased procollagen alpha1(I) mRNA expression and alpha1(I), alpha2(I) and alpha1(III) collagen secretion were observed in dermal fibroblasts obtained from a skin biopsy overlying the involved bone. The patient was a 53-year-old man with melorheostosis lesions over the left knee joint. Multiple pigmented macules were present on the medial aspect of the lower left leg. Hyperpigmentation of the basal keratinocytes, thick-walled vessels in the reticular dermis, and proliferation of normal-appearing collagen around the hair follicles were observed histologically. |
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| Keywords: | collagen fibroblasts fibrosis melorheostosis procollagen |
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