| 环境雌激素对生殖和发育毒性的分子机理 |
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| 引用本文： | 龙鼎新,李勇,陈锋. 环境雌激素对生殖和发育毒性的分子机理[J]. 卫生研究, 2002, 31(2): 139-141 |
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| 作者姓名： | 龙鼎新 李勇 陈锋 |
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| 作者单位： | 北京大学公共卫生学院,北京,100083 |
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| 基金项目： | 国家自然科学基金重点项目 (No 30 0 30 1 2 0) |
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| 摘 要： | 大量动物实验表明环境雌激素具有生殖和／或发育毒性，但其作用机制非常复杂，尤其在分子机理方面不甚明了，本文从信号通路，基因表达，诱变效应等几个方面介绍了近几年来国内外在分子机理研究方面所取得的进展。
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| 关 键 词： | 环境雌激素 雌激素样化合物 生殖毒性 发育毒性 分子机理 |
| 文章编号： | 1000-8020(2002)02-0139-03 |
Molecular mechanisms of environmental estrogens on reproductive and developmental toxicity |
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| Long Dingxin,Li Yong,Chen Feng School of Public Health,Peking University,Beijing ,China. Molecular mechanisms of environmental estrogens on reproductive and developmental toxicity[J]. Journal of hygiene research, 2002, 31(2): 139-141 |
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| Authors: | Long Dingxin Li Yong Chen Feng School of Public Health Peking University Beijing China |
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| Affiliation: | School of Public Health, Peking University, Beijing 100083, China. |
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| Abstract: | It has been shown that numerous natural and synthetic chemicals with estrogenic activities are reproductive or developmental toxic factors in humans or animals by epidemiological investigations and animal experiments. The mechanisms of toxicity, however, are very complicated, especially the molecular mechanisms. This article introduced the current progress on molecular mechanisms of toxicity, which included modulating signaling pathways, interfering gene expression during embryo stage, inducing mutation, etc. |
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| Keywords: | environmental estrogen estrogenic chemical reproductive toxicity developmental toxicity molecular mechanism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
