| PD-1/PD-L1单抗联合放疗治疗实体瘤研究进展 |
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| 引用本文： | 王倩蓉,李宝生.PD-1/PD-L1单抗联合放疗治疗实体瘤研究进展[J].中华放射肿瘤学杂志,2016,25(12):1375-1378. |
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| 作者姓名： | 王倩蓉 李宝生 |
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| 作者单位： | 250022 济南大学山东省医学科学院医学与生命科学学院(王倩蓉);250117济南,山东大学附属山东省肿瘤医院放疗六科(王倩蓉、李宝生) |
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| 基金项目： | 山东省自然科学基金重点项目(ZR2015QZ09).Key Projects of Natural Science Foundation of Shandong Province (ZR2015QZ09) |
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| 摘 要： | PD-1/PD-L1单抗联合放疗可增强抗肿瘤免疫效应,在部分实体瘤临床前试验中疗效显著,有望成为有效的临床治疗模式。PD-1/PD-L1单抗联合放疗的作用机制、联合时机、放疗分割模式与放疗剂量等是本类研究的重点。本文就PD-1/PD-L1单抗联合放疗治疗实体瘤的研究进展进行综述。
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| 关 键 词： | PD-1/PD-L1单抗 免疫疗法 放射疗法 实体瘤 远隔效应 |
| 收稿时间： | 2016-03-02 |
Research progress in PD-1/PD-L1 monoclonal antibody combined with radiotherapy in treatment of solid tumors |
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| Wang Qianrong,Li Baosheng.Research progress in PD-1/PD-L1 monoclonal antibody combined with radiotherapy in treatment of solid tumors[J].Chinese Journal of Radiation Oncology,2016,25(12):1375-1378. |
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| Authors: | Wang Qianrong Li Baosheng |
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| Institution: | School of Medicine and Life Sciences,University of Ji’nan-Shangdong Academy of Medical Sciences,Ji’nan 250022,China (Wang QR);Sixth Department of Radiation Oncology,Shangdong Cancer Hospital Affiliated to Shangdong University,Ji’nan 250117,China (Wang QR,Li BSH) |
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| Abstract: | D-1/PD-L1 monoclonal antibody combined with radiotherapy enhances anti-tumor immune response and achieves substantial treatment outcomes in preclinical studies of some solid tumors. Therefore, the combination therapy is a promising clinical treatment mode for solid tumors. Extensive studies have focused on the mechanism, timing, fractionation mode, and radiation dose of the combination therapy. This paper reviews the research progress in PD-1/PD-L1 monoclonal antibody combined with radiotherapy for treating solid tumors. |
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| Keywords: | Programmed death-1 Programmed death-ligand-1 Immunotherapy Radiotherapy Abscopal effect Solid tumors |
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