| 奥美拉唑和泮托拉唑对氯吡格雷高维持量作用的影响比较 |
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| 引用本文： | 周小兵,王强,李利.奥美拉唑和泮托拉唑对氯吡格雷高维持量作用的影响比较[J].中南药学,2011,9(8):589-592. |
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| 作者姓名： | 周小兵 王强 李利 |
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| 作者单位： | 1. 岳阳县人民医院,湖南,岳阳,414100
2. 湖南理工学院,湖南,岳阳,414000 |
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| 摘 要： | 目的评价2种质子泵抑制药奥美拉唑和泮托拉唑对非ST段抬高急性冠脉综合征(NSTE ACS)患者支架置入术后氯吡格雷效果的影响。方法 140例接受冠脉支架置入的NSTE ACS患者,随机分为对照组、奥美拉唑组和泮托拉唑组。出院时给予阿司匹林75 mg和氯吡格雷150 mg长期口服。血小板反应指数(PRI)磷酸化血小板血管扩张剂刺激磷蛋白(VASP)用于评估氯吡格雷反应和对二磷酸腺苷(ADP)诱导的血小板聚集反应(ADP-Ag)。结果随访1个月的结果显示,接受泮托拉唑的患者血小板氯吡格雷反应性明显优于接受奥美拉唑的患者,PRI VASP为(36.3±6.1)%对(48.2±2.7)%(P<0.01)。但2组间ADP-Ag无显著差异(P>0.05)。结论泮托拉唑对氯吡格雷抗血小板活性的抑制作用小于奥美拉唑。
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| 关 键 词： | 奥美拉唑 泮托拉唑 氯吡格雷 非ST段抬高急性冠脉综合征 血管扩张剂刺激磷蛋白 血小板聚集反应性 |
Effect of omeprazole and pantoprazole on clopidogrel-induced platelet inhibition |
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| ZHOU Xiao-bing,WANG Qiang,LI Li.Effect of omeprazole and pantoprazole on clopidogrel-induced platelet inhibition[J].Central South Pharmacy,2011,9(8):589-592. |
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| Authors: | ZHOU Xiao-bing WANG Qiang LI Li |
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| Institution: | ZHOU Xiao-bing1,WANG Qiang2,LI Li2(1.People's Hospital of Yueyang,Yueyang Hunan 414100,2 Hunan Institute of Science and Technology,Yueyang Hunan 414000) |
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| Abstract: | Objective To investigate the effect of 2 proton pump inhibitors(PPIs),omeprazole and pantoprazole on platelet inhibition induced by clopidogrel.Methods A total of 96 patients undergoing coronary stenting for non-ST-segment elevation acute coronary syndrome were prospectively included and randomized to a non-PPI group,an omeprazole group and a pantoprazole group.They received 75 mg aspirin and 150 mg clopidogrel at discharge.Platelet reactivity index(PRI) vasoactive stimulated phosphoprotein(VASP) was used t... |
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| Keywords: | omeprazole pantoprazole clopidogrel non-ST-segment elevation acute coronary syndrome vasodilator-stimulated phosphoprotein phosphorylation ADP-induced platelet aggregation |
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