| 阿昔洛韦脂质体的制备与稳定性实验的考察 |
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| 引用本文： | 孙春艳,臧恒昌. 阿昔洛韦脂质体的制备与稳定性实验的考察[J]. 齐鲁药事, 2009, 28(4): 231-233 |
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| 作者姓名： | 孙春艳 臧恒昌 |
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| 作者单位： | 1. 山东大学药学院,山东,济南,250012;山东药品食品职业学院,山东,淄博,255011
2. 山东大学药学院,山东,济南,250012 |
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| 摘 要： | 目的利用薄膜分散法将阿昔洛韦制成脂质体改变口服生物利用度低的缺点。方法采用高效液相色谱法测定包封率并对其稳定性进行考察。结果在2～20.0μg·mL-1范围内,呈现良好线性关系(r=0.9999),包封率稳定。结论HPLC能够满足分析的需要,包封率达到90%以上。
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| 关 键 词： | 阿昔洛韦 脂质体 制备 包封率 |
Study on preparation and long-time physical stability experiment of acyclovir-containing liposomes |
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| SUN Chun-yan,ZANG Heng-chang. Study on preparation and long-time physical stability experiment of acyclovir-containing liposomes[J]. qilu pharmaceutical affairs, 2009, 28(4): 231-233 |
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| Authors: | SUN Chun-yan ZANG Heng-chang |
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| Affiliation: | SUN Chun-yan1,2,ZANG Heng-chang1 |
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| Abstract: | OBJECTIVE Using drug membrane method to prepare acyclovir liposomes,which can overcome low bioavailability of oral administration. METHODS Through HPLC to determine and to inspect the entrapment efficiency （EN%）. RESULTS The linear concentration range was 2 - 20. 0μg · mL^-1 （ r = 0. 9999）, EN% was stable. CONCLUSION HPLC method can satisfy the needs of analysis,the EN% was up to 90%. |
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| Keywords: | Acyclovir liposomes preparation entrapment efficiency |
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