| Effects of experimental varicocele on mitochondria calcium and cytochrome C of epididymis in adolescent rats |
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| 引用本文： | Xiao-RuMa Shu-QiuWang Yue-XinWang Shu-XiangWang Wei-QunWang Jian-HuaZhang Yong-YiLi. Effects of experimental varicocele on mitochondria calcium and cytochrome C of epididymis in adolescent rats[J]. Asian journal of andrology, 2004, 6(3): 248-248 |
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| 作者姓名： | Xiao-RuMa Shu-QiuWang Yue-XinWang Shu-XiangWang Wei-QunWang Jian-HuaZhang Yong-YiLi |
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| 作者单位： | [1]DepartmentofPathophysiology [2]BiochemicalPreventionLaboratorym [3]HumanBodyFunctionLaboratoryJiamusiUniversityBasicMedicalScienceCollege,Jiamusi154007,China |
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| 摘 要： | Aim: To investigate the effect of experimental varicocele on mitochondrial calcium and cytochrome C of the epididymal cells in adolescent rats. Methods: Forty male adult Wistar rats were divided into two groups randomly: the varicocele group (VG) and the sham operated group (SOG). Varicocele was produced by partial ligation of the left renal vein. Bilateral epididymides were removed after ten weeks. The mitochondrial calcium and cytochrome C levels of the epididymal cells were determined. Results: The mi-tochondrial calcium was decreased (P<0.01) while the cytochrome C increased (P<0.05) markedly in the experimental group compared with the controls. Conclusion: Varicocele-induced calcium dyshomeostasis and mitochondrial damage of the epididymal cells may play an important role in causing subfertility.
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| 关 键 词： | 实验性 精索静脉曲张 线粒体 钙离子 细胞凋亡 |
Effects of experimental varicocele on mitochondria calcium and cytochrome C of epididymis in adolescent rats |
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| Xiao-Ru Ma,Shu-Qiu Wang,Yue-Xin Wang,Shu-Xiang Wang,Wei-Qun Wang,Jian-Hua Zhang,Yong-Yi Li. Effects of experimental varicocele on mitochondria calcium and cytochrome C of epididymis in adolescent rats[J]. Asian journal of andrology, 2004, 6(3): 248-248 |
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| Authors: | Xiao-Ru Ma Shu-Qiu Wang Yue-Xin Wang Shu-Xiang Wang Wei-Qun Wang Jian-Hua Zhang Yong-Yi Li |
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| Affiliation: | Xiao-Ru Ma,Shu-Qiu Wang,Yue-Xin Wang,Shu-Xiang Wang,Wei-Qun Wang,Jian-Hua Zhang,Yong-Yi LiDepartment of Pathophysiology,Biochemical PreventionLaboratorym,Human Body Function Laboratory,JiamusiUniversity Basic Medical Science College,Jiamusi 154007,China |
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| Abstract: | Aim: To investigate the effect of experimental varicocele on mitochondrial calcium and cytochrome C of the epididymal cells in adolescent rats. Methods: Forty male adult Wistar rats were divided into two groups randomly: the varicocele group (VG) and the sham operated group (SOG). Varicocele was produced by partial ligation of the left renal vein. Bilateral epididymides were removed after ten weeks. The mitochondrial calcium and cytochrome C levels of the epididymal cells were determined. Results: The mi-tochondrial calcium was decreased (P<0.01) while the cytochrome C increased (P<0.05) markedly in the experimental group compared with the controls. Conclusion: Varicocele-induced calcium dyshomeostasis and mitochondrial damage of the epididymal cells may play an important role in causing subfertility. |
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| Keywords: | varicocele epididymis mitochondrial calcium cyto-chrome C apoptosis |
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